MedStar Authors catalog › Details for: Intravenous administration of multipotent stromal cells and bone allograft modification to enhance allograft healing.
Normal view MARC view ISBD view

Intravenous administration of multipotent stromal cells and bone allograft modification to enhance allograft healing.

by Lee, Moses; Lee, Wen; Mitchell, Reed; Paudel, Sharada; Schon, Lew C; Zahoor, Talal; Zhang, Zijun.
Citation: Regenerative Medicine. 14(3):199-211, 2019 03.; .Journal: Regenerative medicine.Published: 2019; ; ISSN: 1746-0751.Full author list: Lee M; Lee WH; Mitchell R; Paudel S; Schon L; Yang SY; Zahoor T; Zhang Z; Zhao H.UI/PMID: 30761943.Subject(s): *Bone Transplantation | *Mesenchymal Stem Cell Transplantation/mt [Methods] | *Mesenchymal Stem Cells/cy [Cytology] | *Multipotent Stem Cells/cy [Cytology] | *Osteogenesis | *Stromal Cells/cy [Cytology] | *Wound Healing | Administration, Intravenous | Allografts | Animals | Cells, Cultured | Humans | Mice | Mice, NudeInstitution(s): MedStar Union Memorial Hospital | MedStar Washington Hospital CenterDepartment(s): Orthobiologic Laboratory | Orthopaedic Surgery | PathologyActivity type: Journal Article.Medline article type(s): Journal ArticleDigital Object Identifier: https://dx.doi.org/10.2217/rme-2018-0063 (Click here) Abbreviated citation: Regen. med.. 14(3):199-211, 2019 03; .Abstract: AIM: This study investigated a coordinated strategy of revitalizing bone allograft with circulating multipotent stromal cells (MSCs).Abstract: CONCLUSION: Coating bone allograft with stromal cell-derived factor 1 and platelet-derived growth factor BB and intravenous injections of MSCs improved allograft incorporation.Abstract: MATERIALS & METHODS: After chemotactic and releasing assessments, stromal cell-derived factor 1 and platelet-derived growth factor BB in copolymers were coated on the bone allograft (Allo<sub>S-P</sub>). Allograft coated with copolymers alone (Allo), as controls, or Allo<sub>S-P</sub> was implanted into the femur of athymic mice, which received intravenous injections of human MSCs or saline at weeks 1, 2 and 3.Abstract: RESULTS: At week 8, the total callus volume (both cartilaginous and bony callus) around the allograft was the largest in the Allo<sub>S-P</sub> + MSC group (p < 0.05).

Powered by Koha