MedStar Authors catalog › Details for: Intravenous administration of multipotent stromal cells and bone allograft modification to enhance allograft healing.
Citation: Regenerative Medicine. 14(3):199-211, 2019 03.; .Journal: Regenerative medicine.Published: 2019; ; ISSN: 1746-0751.Full author list: Lee M; Lee WH; Mitchell R; Paudel S; Schon L; Yang SY; Zahoor T; Zhang Z; Zhao H.UI/PMID: 30761943.Subject(s): *Bone Transplantation | *Mesenchymal Stem Cell Transplantation/mt [Methods] | *Mesenchymal Stem Cells/cy [Cytology] | *Multipotent Stem Cells/cy [Cytology] | *Osteogenesis | *Stromal Cells/cy [Cytology] | *Wound Healing | Administration, Intravenous | Allografts | Animals | Cells, Cultured | Humans | Mice | Mice, NudeInstitution(s): MedStar Union Memorial Hospital | MedStar Washington Hospital CenterDepartment(s): Orthobiologic Laboratory | Orthopaedic Surgery | PathologyActivity type: Journal Article.Medline article type(s): Journal ArticleDigital Object Identifier: https://dx.doi.org/10.2217/rme-2018-0063 (Click here)Abbreviated citation: Regen. med.. 14(3):199-211, 2019 03; .Abstract: AIM: This study investigated a coordinated strategy of revitalizing bone allograft with circulating multipotent stromal cells (MSCs).Abstract: CONCLUSION: Coating bone allograft with stromal cell-derived factor 1 and platelet-derived growth factor BB and intravenous injections of MSCs improved allograft incorporation.Abstract: MATERIALS & METHODS: After chemotactic and releasing assessments, stromal cell-derived factor 1 and platelet-derived growth factor BB in copolymers were coated on the bone allograft (Allo<sub>S-P</sub>). Allograft coated with copolymers alone (Allo), as controls, or Allo<sub>S-P</sub> was implanted into the femur of athymic mice, which received intravenous injections of human MSCs or saline at weeks 1, 2 and 3.Abstract: RESULTS: At week 8, the total callus volume (both cartilaginous and bony callus) around the allograft was the largest in the Allo<sub>S-P</sub> + MSC group (p < 0.05).
