Non-invasive in situ Visualization of the Murine Cranial Vasculature.

MedStar author(s):
Citation: Cell Reports Methods. 2(1), 2022 Jan 24.PMID: 35373177Department: MedStar Georgetown University Hospital/MedStar Washington Hospital Center | Neurosurgery ResidencyForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: IN PROCESS -- NOT YET INDEXEDYear: 2022ISSN:
  • 2667-2375
Name of journal: Cell reports methodsAbstract: Understanding physiologic and pathologic central nervous system function depends on our ability to map the entire in situ cranial vasculature and neurovascular interfaces. To accomplish this, we developed a non-invasive workflow to visualize murine cranial vasculature via polymer casting of vessels, iterative sample processing and micro-computed tomography, and automatic deformable image registration, feature extraction, and visualization. This methodology is applicable to any tissue and allows rapid exploration of normal and altered pathologic states.All authors: Bryant JP, Cappadona AJ, Chandrashekhar V, Chandrashekhar V, Donahue DR, Heiss JD, Knutsen RH, Kozel B, Lookian PP, McGavern DB, Rosenblum JS, Zhao DY, Zhuang ZFiscal year: FY2022Digital Object Identifier: Date added to catalog: 2022-05-11
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Journal Article MedStar Authors Catalog Article 35373177 Available 35373177

Understanding physiologic and pathologic central nervous system function depends on our ability to map the entire in situ cranial vasculature and neurovascular interfaces. To accomplish this, we developed a non-invasive workflow to visualize murine cranial vasculature via polymer casting of vessels, iterative sample processing and micro-computed tomography, and automatic deformable image registration, feature extraction, and visualization. This methodology is applicable to any tissue and allows rapid exploration of normal and altered pathologic states.

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