Gastric carcinoma's primary presentation as multiple cutaneous nodules throughout the body.

MedStar author(s):
Citation: Cancer Treatment And Research Communications. 31:100532, 2022 Feb 12.PMID: 35217487Institution: MedStar Washington Hospital CenterDepartment: DermatologyForm of publication: Journal ArticleMedline article type(s): Journal ArticleYear: 2022ISSN:
  • 2468-2942
Name of journal: Cancer treatment and research communicationsAbstract: Cutaneous metastasis resulting from internal primary tumors remains a rare phenomenon. The prompt recognition of these metastases is important, as they are an indicator of advanced disease and poor prognosis. We report the case of a 44-year-old Caucasian man presenting with a four-month history of multiple cutaneous nodules on the face, trunk, and upper extremities. Results from skin biopsy revealed strands and cords of atypical cells concerning for poorly differentiated metastatic carcinoma. An esophagogastroduodenoscopy was performed and a poorly differentiated signet-ring type invasive adenocarcinoma at the lesser curvature of the stomach was found. As the cancer had already metastasized to the skin and bones, the patient was started on chemotherapy with an oxaliplatin-based regimen and denosumab for the bone metastases, with resultant objective response and diagnostic control for greater than one year to the present date. Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.All authors: Bajoghli AA, Cardis MA, Kemprecos H, Khosravi H, Noel MS, Piselli AFiscal year: FY2022Digital Object Identifier: Date added to catalog: 2022-03-17
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Journal Article MedStar Authors Catalog Article 35217487 Available 35217487

Cutaneous metastasis resulting from internal primary tumors remains a rare phenomenon. The prompt recognition of these metastases is important, as they are an indicator of advanced disease and poor prognosis. We report the case of a 44-year-old Caucasian man presenting with a four-month history of multiple cutaneous nodules on the face, trunk, and upper extremities. Results from skin biopsy revealed strands and cords of atypical cells concerning for poorly differentiated metastatic carcinoma. An esophagogastroduodenoscopy was performed and a poorly differentiated signet-ring type invasive adenocarcinoma at the lesser curvature of the stomach was found. As the cancer had already metastasized to the skin and bones, the patient was started on chemotherapy with an oxaliplatin-based regimen and denosumab for the bone metastases, with resultant objective response and diagnostic control for greater than one year to the present date. Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.

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