MedStar Authors catalog › Details for: Apical Resection and Cryoinjury of Neonatal Mouse Heart.
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Apical Resection and Cryoinjury of Neonatal Mouse Heart.

by Darehzereshki, Ali.
Citation: Methods in Molecular Biology. 2158:23-32, 2021.; .Journal: Methods in molecular biology (Clifton, N.J.).Published: 2021; ; ; ISSN: 1064-3745.Full author list: Darehzereshki A; Lien CL; Shen H; Sucov HM.UI/PMID: 32857362.Subject(s): *Cardiac Surgical Procedures/ae [Adverse Effects] | *Cryosurgery/ae [Adverse Effects] | *Heart Injuries/pa [Pathology] | *Heart/ph [Physiology] | *Regeneration | *Ventricular Remodeling | Animals | Animals, Newborn | Cell Proliferation | Female | Heart Injuries/et [Etiology] | Heart Injuries/rh [Rehabilitation] | Male | MiceInstitution(s): MedStar Franklin Square Medical CenterDepartment(s): SurgeryActivity type: Journal Article.Medline article type(s): Journal ArticleDigital Object Identifier: (Click here) Abbreviated citation: Methods Mol Biol. 2158:23-32, 2021; .Abstract: Neonatal mouse hearts have a regenerative capacity similar to adult zebrafish. Different cardiac injury models have been established to investigate the regenerative capacity of neonatal mouse hearts, including ventricular amputation, cryoinjury, and ligation of a major coronary artery. While the ventricular resection model can be utilized to study how tissue forms and regenerates de novo, cryoinjury and coronary artery ligation are methods that might better mimic myocardial infarction by creating tissue damage and necrosis as opposed to the removal of healthy tissue in the ventricular amputation model. Here we describe methods of creating ventricular resection and cardiac cryoinjury in newborn mice.

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