MedStar Authors catalog › Details for: Abscopal effect in pulmonary carcinoid tumor following ablative stereotactic body radiation therapy: a case report.
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Abscopal effect in pulmonary carcinoid tumor following ablative stereotactic body radiation therapy: a case report.

by Kareff, Samuel.
Citation: Journal of Medical Case Reports [Electronic Resource]. 14(1):177, 2020 Oct 04..Journal: Journal of medical case reports.Published: ; 2020ISSN: 1752-1947.Full author list: Kareff SA; Lischalk JW; Krochmal R; Kim C.UI/PMID: 33010806.Subject(s): IN PROCESS -- NOT YET INDEXEDInstitution(s): MedStar Washington Hospital CenterDepartment(s): Medicine/Internal MedicineActivity type: Journal Article.Medline article type(s): Journal ArticleOnline resources: Click here to access online Digital Object Identifier: https://dx.doi.org/10.1186/s13256-020-02512-8 (Click here) Abbreviated citation: J Med Case Reports. 14(1):177, 2020 Oct 04.Abstract: BACKGROUND: The abscopal effect was described as early as the 1950s, when untreated tumors demonstrated a response after radiation therapy was delivered to an untreated, distant site. The mechanisms underlying this global response to otherwise localized therapy remain unknown, though there is increasing evidence that increased antigen expression following ablative radiotherapy may play a role.Abstract: CASE PRESENTATION: We report a case of a 69-year-old African American woman with a history of metastatic typical pulmonary carcinoid with multiple lung nodules who had a significant decrease in size of an untreated left upper lobe nodule after stereotactic body radiation therapy to an oligoprogressive left lower lobe lesion.Abstract: CONCLUSIONS: To our knowledge, this report describes the first case of an abscopal effect in a typical pulmonary carcinoid. Further research is needed regarding the mechanisms responsible for this finding and the role of combining radiation therapy and cancer immunotherapy in patients with pulmonary carcinoid tumors.

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