TY  - BOOK
AU  - Aghili, Nima
AU  - Burnett, Mary Susan
AU  - Epstein, Stephen E
AU  - Jhamnani, Sunny
AU  - Lassance-Soares, Roberta M
AU  - Nashin, Hajra
AU  - Sood, Subeena
TI  - Chronic stress impairs collateral blood flow recovery in aged mice
KW  - *Collateral Circulation
KW  - *Femoral Artery/pp [Physiopathology]
KW  - *Ischemia/pp [Physiopathology]
KW  - *Stress, Psychological/pp [Physiopathology]
KW  - Animals
KW  - Behavior, Animal
KW  - Chronic Disease
KW  - Cold Temperature
KW  - Disease Models, Animal
KW  - Femoral Artery/su [Surgery]
KW  - Ischemia/et [Etiology]
KW  - Ischemia/px [Psychology]
KW  - Ligation
KW  - Male
KW  - Mice, Inbred C57BL
KW  - Recovery of Function
KW  - Regional Blood Flow
KW  - Social Behavior
KW  - Stress, Psychological/et [Etiology]
KW  - Stress, Psychological/px [Psychology]
KW  - Time Factors
KW  - MedStar Health Research Institute
KW  - MedStar Heart & Vascular Institute
KW  - MedStar Washington Hospital Center
KW  - Medicine/Internal Medicine
KW  - Journal Article
KW  - Research Support, N.I.H., Extramural
KW  - Research Support, Non-U.S. Gov't
N2  - Chronic stress is associated with increased risk of cardiovascular diseases. Aging is also associated with vascular dysfunction. We hypothesize that chronic stress accelerates collateral dysfunction in old mice. Mice were subjected to either chronic social defeat (CSD) or chronic cold stress (CCS). The CSD mice were housed in a box inside an aggressor's cage and exposed to the aggressor. The CCS group was placed in iced water. After chronic stress, mice underwent femoral artery ligation (FAL) and flow recovery was measured. For the CSD group, appearance and use scores of the foot and a behavioral test were performed. CSD impaired collateral flow recovery after FAL. Further, stressed mice had greater ischemic damage, impaired foot function, and altered behavior. The CCS mice also showed impaired collateral flow recovery. Chronic stress causes hind limb collateral dysfunction in old mice, a conclusion reinforced by the fact that two types of stress produced similar changes
UR  - http://dx.doi.org/10.1007/s12265-014-9592-2
ER  -