TY  - BOOK
AU  - Dieter, Alexis A
TI  - Nonestrogen Therapies for Treatment of Genitourinary Syndrome of Menopause: A Systematic Review
SN  - 0029-7844
PY  - 2023///
KW  - *Hyaluronic Acid
KW  - *Menopause
KW  - Dehydroepiandrosterone/ae [Adverse Effects]
KW  - Dehydroepiandrosterone/tu [Therapeutic Use]
KW  - Estrogens/tu [Therapeutic Use]
KW  - Female
KW  - Humans
KW  - Hyaluronic Acid/pd [Pharmacology]
KW  - Hyaluronic Acid/tu [Therapeutic Use]
KW  - Testosterone/pd [Pharmacology]
KW  - Vagina
KW  - MedStar Washington Hospital Center
KW  - Obstetrics and Gynecology
KW  - Journal Article
KW  - Systematic Review
N1  - Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006
N2  - CONCLUSION: Most nonestrogen therapies are effective treatments for the various symptoms of GSM. There are insufficient data to compare nonestrogen options to each other. Copyright © 2023 by the American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved; DATA SOURCES: MEDLINE, EMBASE, ClinicalTrials.gov , and Cochrane databases were searched from inception to July 2021. We included comparative and noncomparative studies. Interventions and comparators were limited to seven products that are commercially available and currently in use (vaginal dehydroepiandrosterone [DHEA], ospemifene, laser or energy-based therapies, polycarbophil-based vaginal moisturizer, Tibolone, vaginal hyaluronic acid, testosterone). Topical estrogen, placebo, other nonestrogen products, as well as no treatment were considered as comparators; METHODS OF STUDY SELECTION: We double-screened 9,131 abstracts and identified 136 studies that met our criteria. Studies were assessed for quality and strength of evidence by the systematic review group; OBJECTIVE: To systematically review the literature and provide clinical practice guidelines regarding various nonestrogen therapies for treatment of genitourinary syndrome of menopause (GSM); TABULATION, INTEGRATION, AND RESULTS: Information regarding the participants, details on the intervention and comparator and outcomes were extracted from the eligible studies. Alternative therapies were similar or superior to estrogen or placebo with minimal increase in adverse events. Dose response was noted with vaginal DHEA and testosterone. Vaginal DHEA, ospemifene, erbium and fractional carbon dioxide (CO 2 ) laser, polycarbophil-based vaginal moisturizer, tibolone, hyaluronic acid, and testosterone all improved subjective and objective signs of atrophy. Vaginal DHEA, ospemifene, tibolone, fractional CO 2 laser, polycarbophil-based vaginal moisturizer, and testosterone improved sexual function
UR  - https://dx.doi.org/10.1097/AOG.0000000000005288
ER  -