TY - BOOK AU - Sullivan, Shannon D TI - Changes in physical activity and body composition in postmenopausal women over time SN - 0195-9131 PY - 2013/// KW - *Body Composition/ph [Physiology] KW - *Exercise/ph [Physiology] KW - *Postmenopause/ph [Physiology] KW - Absorptiometry, Photon KW - Adipose Tissue/ph [Physiology] KW - Aged KW - Aged, 80 and over KW - Female KW - Humans KW - Longitudinal Studies KW - Middle Aged KW - Prospective Studies KW - MedStar Washington Hospital Center KW - Medicine/Endocrinology KW - Journal Article KW - Research Support, N.I.H., Extramural N1 - Available online from MWHC library: 1996 - present N2 - CONCLUSIONS: The association between PA and change in fat mass varies by age group, with younger, but not older, women benefiting from higher levels of aerobic PA. Higher levels of aerobic activity are not associated with changes in lean mass, which tends to decrease in older women regardless of activity level. Greater attention to resistance training exercises may be needed to prevent lean mass loss as women age; METHODS: Among 11,491 women enrolled at three Women's Health Initiative clinical centers who were selected to undergo dual-energy x-ray absorptiometry, 8352 had baseline body composition measurements, with at least one repeated measure at years 1, 3, and 6. PA data were obtained by self-report at baseline and 3 and 6 yr of follow-up. Time-varying PA effect on change in lean and fat mass during the 6-yr study period for age groups (50-59 yr, 60-69 yr, and 70-79 yr) was estimated using mixed effects linear regression; PURPOSE: Higher physical activity (PA) has been associated with greater attenuation of body fat gain and preservation of lean mass across the lifespan. These analyses aimed to determine relationships of change in PA to changes in fat and lean body mass in a longitudinal prospective study of postmenopausal women; RESULTS: Baseline PA and body composition differed significantly among the three age groups. The association of change in fat mass from baseline and time-varying PA differed across the three age groups (P = 0.0006). In women age 50-59 yr, gain in fat mass from baseline was attenuated with higher levels of PA. Women age 70-79 yr lost fat mass at all PA levels. In contrast, change in lean mass from baseline and time-varying PA did not differ by age group (P = 0.1935) UR - http://dx.doi.org/10.1249/MSS.0b013e31828af8bd ER -