TY  - BOOK
AU  - Howard, Barbara V
AU  - Howard, William J
AU  - Umans, Jason G
TI  - Differences in risk factors for coronary heart disease among diabetic and nondiabetic individuals from a population with high rates of diabetes: the Strong Heart Study
SN  - 0021-972X
PY  - 2012///
KW  - *Coronary Disease/eh [Ethnology]
KW  - *Coronary Disease/mo [Mortality]
KW  - *Diabetes Mellitus/eh [Ethnology]
KW  - *Diabetes Mellitus/mo [Mortality]
KW  - *Indians, North American/sn [Statistics & Numerical Data]
KW  - Aged
KW  - Female
KW  - Follow-Up Studies
KW  - Humans
KW  - Hypertension/eh [Ethnology]
KW  - Hypertension/mo [Mortality]
KW  - Incidence
KW  - Male
KW  - Middle Aged
KW  - Morbidity
KW  - Multivariate Analysis
KW  - Myocardial Infarction/eh [Ethnology]
KW  - Myocardial Infarction/mo [Mortality]
KW  - Prevalence
KW  - Proportional Hazards Models
KW  - Risk Factors
KW  - MedStar Health Research Institute
KW  - MedStar Washington Hospital Center
KW  - Medicine/General Internal Medicine
KW  - Comparative Study
KW  - Journal Article
KW  - Research Support, N.I.H., Extramural
N1  - Available online from MWHC library: 1997 - present, Available in print through MWHC library: 1999 - 2006
N2  - CONCLUSIONS: In addition to higher incidence rates of CHD events in persons with diabetes compared with those without, the two groups differed in CHD risk factors. These differences must be recognized in estimating CHD risk and managing risk factors; CONTEXT: Coronary heart disease (CHD) is the leading cause of death in the United States; DESIGN: This was an observational study; INTERVENTION(S): CHD events were ascertained during follow-up; MAIN OUTCOME MEASURE: CHD events were classified using standardized criteria; OBJECTIVE: This study compares differences in risk factors for CHD in diabetic vs. nondiabetic Strong Heart Study participants; PARTICIPANTS: Data were obtained from 3563 of 4549 American Indians free of cardiovascular disease at baseline; RESULTS: In diabetic and nondiabetic participants, 545 and 216 CHD events, respectively, were ascertained during follow-up (21,194 and 22,990 person-years); age- and sex-adjusted incidence rates of CHD were higher for the diabetic group (27.5 vs. 12.1 per 1,000 person-years). Risk factors for incident CHD common to both groups included older age, male sex, prehypertension or hypertension, and elevated low-density lipoprotein cholesterol. Risk factors specific to the diabetic group were lower high-density lipoprotein cholesterol, current smoking, macroalbuminuria, lower estimated glomerular filtration rate, use of diabetes medication, and longer duration of diabetes. Higher body mass index was a risk factor only for the nondiabetic group. The association of male sex and CHD was greater in those without diabetes than in those with diabetes; SETTING: The study was conducted at three centers in Arizona, Oklahoma, and North and South Dakota
UR  - http://dx.doi.org/10.1210/jc.2012-2110
ER  -