TY  - BOOK
AU  - Chesney, Kelsi
AU  - Keating, Gregory
AU  - Patel, Nirali
TI  - The role of focused ultrasound for pediatric brain tumors: current insights and future implications on treatment strategies
SN  - 0256-7040
PY  - 2024///
KW  - IN PROCESS -- NOT YET INDEXED
KW  - Automated
KW  - MedStar Georgetown University Hospital/MedStar Washington Hospital Center
KW  - Neurosurgery Residency
KW  - Journal Article
N2  - CONCLUSION: Discussions regarding future applications of FUS for the treatment of gliomas include improved drug delivery, immunomodulation, radiosensitization, and other technological advancements. Copyright © 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature; INTRODUCTION: Focused ultrasound (FUS) is an innovative and emerging technology for the treatment of adult and pediatric brain tumors and illustrates the intersection of various specialized fields, including neurosurgery, neuro-oncology, radiation oncology, and biomedical engineering; METHODS: The fundamental principles of FUS include its ability to induce thermal ablation or enhance drug delivery through transient blood-brain barrier (BBB) disruption, emphasizing the adaptability of high-intensity focused ultrasound (HIFU) and low-intensity focused ultrasound (LIFU) applications; OBJECTIVE: The authors provide a comprehensive overview of the application and implications of FUS in treating pediatric brain tumors, with a special focus on pediatric low-grade gliomas (pLGGs) and the evolving landscape of this technology and its clinical utility; RESULTS: Several ongoing clinical trials explore the potential of FUS in offering alternative therapeutic strategies for pathologies where conventional treatments fall short, specifically centrally-located benign CNS tumors and diffuse intrinsic pontine glioma (DIPG). A case illustration involving the use of HIFU for pilocytic astrocytoma is presented
UR  - https://dx.doi.org/10.1007/s00381-024-06413-9
ER  -