TY  - BOOK
AU  - Epstein, Stephen E
AU  - Lipinski, Michael J
AU  - Luger, Dror
AU  - Waksman, Ron
AU  - Westman, Peter C
TI  - Inflammation as a Driver of Adverse Left Ventricular Remodeling After Acute Myocardial Infarction. [Review]
SN  - 0735-1097
PY  - 2016///
KW  - *Inflammation/pp [Physiopathology]
KW  - *Myocardial Infarction/pp [Physiopathology]
KW  - *Ventricular Remodeling/ph [Physiology]=520  \\
KW  - Treatment of acute myocardial infarction (AMI) has improved significantly in recent years, but many patients have adverse left ventricular (LV) remodeling, a maladaptive change associated with progressive heart failure. Although this change is usually associated with large infarcts, some patients with relatively small infarcts have adverse remodeling, whereas other patients with larger infarcts (who survive the first several days after AMI) do not. This paper reviews the relevant data supporting the hypothesis that individual differences in the intensity of the post-AMI inflammatory response, involving 1 or more inflammatory-modulating pathways, may contribute to adverse LV remodeling. It concludes by outlining how individual variations in the inflammatory response could provide important novel therapeutic targets and strategies.
KW  - Autoimmune Diseases/co [Complications]
KW  - Biomarkers/me [Metabolism]
KW  - Cytokines/ai [Antagonists & Inhibitors]
KW  - Cytokines/me [Metabolism]
KW  - Humans
KW  - Infection/co [Complications]
KW  - Inflammasomes/ai [Antagonists & Inhibitors]
KW  - Inflammation/pc [Prevention & Control]
KW  - Mesenchymal Stem Cell Transplantation
KW  - Myocardium/me [Metabolism]
KW  - Neovascularization, Physiologic
KW  - Neutrophils/me [Metabolism]
KW  - Polymorphism, Genetic
KW  - Stroke Volume/ph [Physiology]
KW  - MedStar Heart & Vascular Institute
KW  - Journal Article
KW  - Review
N1  - Available online from MWHC library: 1995 - present, Available in print through MWHC library:1999-2007
N2  - Copyright � 2016 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved
UR  - https://dx.doi.org/10.1016/j.jacc.2016.01.073
ER  -