TY  - BOOK
AU  - Ertreo, Marco
TI  - Comparison of Cone-Beam Tomography and Cross-Sectional Imaging for Volumetric and Dosimetric Calculations in Resin Yttrium-90 Radioembolization
SN  - 0174-1551
PY  - 2018///
KW  - *Brachytherapy/mt [Methods]
KW  - *Cone-Beam Computed Tomography/mt [Methods]
KW  - *Liver Neoplasms/rt [Radiotherapy]
KW  - *Magnetic Resonance Imaging/mt [Methods]
KW  - *Radiotherapy Planning, Computer-Assisted/mt [Methods]
KW  - *Yttrium Radioisotopes/tu [Therapeutic Use]
KW  - Adult
KW  - Aged
KW  - Aged, 80 and over
KW  - Contrast Media
KW  - Female
KW  - Humans
KW  - Image Enhancement/mt [Methods]
KW  - Liver Neoplasms/dg [Diagnostic Imaging]
KW  - Liver Neoplasms/pa [Pathology]
KW  - Liver/dg [Diagnostic Imaging]
KW  - Liver/pa [Pathology]
KW  - Liver/re [Radiation Effects]
KW  - Male
KW  - Middle Aged
KW  - Multimodal Imaging/mt [Methods]
KW  - Organ Size
KW  - Radiotherapy Dosage
KW  - Retrospective Studies
KW  - Tomography, X-Ray Computed/mt [Methods]
KW  - MedStar Washington Hospital Center
KW  - Radiology
KW  - Journal Article
N2  - CONCLUSIONS: Although volume measurements derived from CT/MRI did not differ significantly from those derived from CBCT, variability between the two methods led to large and unexpected differences in calculated dose; MATERIALS AND METHODS: The study retrospectively assessed 47 consecutive patients who underwent resin Y-90 radioembolization consecutively over a 2-year period at a single center. Volume calculation software was used to determine perfused lobar liver volumes from cone-beam CT (CBCT) images obtained during mapping angiography. CBCT-derived volumes were compared with perfused lobar volume derived from contrast-enhanced CT and MRI. Nominal activities as determined by the SIR-Spheres Microspheres Activity Calculator were similarly calculated and compared using both CBCT and conventionally acquired volumes; PURPOSE: To compare the use of cone-beam computed tomography versus contrast-enhanced computed tomography (CT) and magnetic resonance imaging (MRI) in the calculation of liver volume and planned dose for yttrium-90 radioembolization; RESULTS: A total of 82 hepatic lobes were assessed in 47 patients. The mean percentage difference between combined CT-MRI- and CBCT-derived calculated lobar volumes was 25.3% (p=0.994). The mean percentage difference in calculated dose between the two methods was 21.8+/-24.6% (p=0.42). Combined left and right lobar CT-derived dose difference was less than 10% in 22 lobes, between 10 and 25% in 20 lobes, between 25 and 50% in 13 lobes and greater than 50% in 5 lobes. Combined left and right lobar MRI-derived dose difference was less than 10% in 11 lobes, between 10 and 25% in 7 lobes, between 25 and 50% in 2 lobes and greater than 50% in 1 lobe
UR  - https://dx.doi.org/10.1007/s00270-018-2030-0
ER  -