TY  - BOOK
AU  - Carvalho, Filipe
AU  - Egan, Jillian
AU  - Hwang, Jonathan J
AU  - Krasnow, Ross
AU  - Lynch, John H
AU  - Stamatakis, Lambros
AU  - Zeymo, Alexander
TI  - Determinants of neoadjuvant chemotherapy use in muscle-invasive bladder cancer
SN  - 2466-0493
PY  - 2020///
KW  - *Antineoplastic Agents/tu [Therapeutic Use]
KW  - *Chemotherapy, Adjuvant/sn [Statistics & Numerical Data]
KW  - *Cisplatin/tu [Therapeutic Use]
KW  - *Neoadjuvant Therapy/sn [Statistics & Numerical Data]
KW  - *Urinary Bladder Neoplasms/dt [Drug Therapy]
KW  - Adolescent
KW  - Adult
KW  - Aged
KW  - Aged, 80 and over
KW  - Female
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - Neoplasm Invasiveness
KW  - Retrospective Studies
KW  - Urinary Bladder Neoplasms/pa [Pathology]
KW  - Young Adult
KW  - MedStar Health Research Institute
KW  - MedStar Washington Hospital Center
KW  - Urology
KW  - Journal Article
N2  - Conclusions: Our study demonstrates that NAC is underutilized. Decreased utilization of NAC was associated with older patients and higher Charlson score. This underutilization may be related to practice patterns as very few patients have true contraindications. Copyright (c) The Korean Urological Association, 2020; Materials and Methods: We identified 5,915 patients diagnosed with cT2-T3N0M0 MIBC who underwent RC between 2004 and 2014 from the National Cancer Database. Univariate and multivariable models were created to identify variables associated with NAC utilization; Purpose: Cisplatin-based neoadjuvant chemotherapy (NAC) followed by radical cystectomy (RC) is standard of care for muscle-invasive bladder cancer (MIBC). However, NAC is used in less than 20% of patients with MIBC. Our goal is to investigate factors that contribute to underutilization NAC to facilitate more routine incorporation into clinical practice; Results: Only 18.8% of patients received NAC during the study period. On univariate analyses, NAC utilization was more likely at academic hospitals, US South and Midwest (p<0.05). Higher Charlson score was associated with decrease use of NAC (p<0.05). On multivariate analysis, treatment in academic hospitals (odds ratio [OR], 1.367; 95% confidence interval [CI], 1.186-1.576), in the Midwest (OR, 1.538; 95% CI, 1.268-1.977) and South (OR, 1.424; 95% CI, 1.139-1.781) were independently associated with NAC utilization. Older age (75 to 84 years old; OR, 0.532; 95% CI, 0.427-0.664) and higher Charlson score (OR, 0.607; 95% CI, 0.439-0.839) were associated with decreased NAC utilization. Sixty-eight percent of patients did not receive NAC because it was not planned and only 2.5% of patients had contraindications for NAC treatment
UR  - https://dx.doi.org/10.4111/icu.2020.61.4.390
ER  -