TY - BOOK AU - Bhogal, Sukhdeep AU - Dan, Kazuhiro AU - Devineni, Aditya AU - Garcia-Garcia, Hector M AU - Hellinga, David AU - Kuku, Kayode O AU - Melaku, Gebremedhin AU - Waksman, Ron TI - Optical coherence tomography assessment of acute thrombogenicity at bifurcation sites using different stenting techniques: A porcine arteriovenous shunt study SN - 1522-1946 PY - 2022/// KW - *Stents KW - *Tomography, Optical Coherence KW - Animals KW - Everolimus KW - Humans KW - Polymers KW - Prosthesis Design KW - Sirolimus KW - Swine KW - Treatment Outcome KW - MedStar Health Research Institute KW - MedStar Heart & Vascular Institute KW - MedStar Washington Hospital Center KW - Advanced Cardiac Catheterization Research Fellowship KW - Journal Article N1 - Available online from MWHC library: 1996 - present, Available in print through MWHC library: 1996 - 2006 N2 - BACKGROUND: The mechanism of thrombogenicity, which differs among second-generation stents implanted using double-kissing (DK) crush or culotte stenting techniques, remains unclear. We have shown previously that setting up a porcine arteriovenous shunt model is feasible and useful to assess thrombogenicity at vessel bifurcation points; CONCLUSIONS: The study provides hypothesis-generating findings in distinct thrombogenicity of bifurcation stenting with DP- or ABP-coated drug-eluting stents. Copyright © 2022 Wiley Periodicals LLC; METHODS: Six porcine shunt models were prepared for the comparison between DK crush and culotte stenting techniques using BMS, DP-EES, and ABP-SES. Intracoronary imaging with high-resolution optical coherence tomography (OCT) was performed to evaluate the thrombogenicity in different stent types in the bifurcation stenting model and was evaluated by a core lab; OBJECTIVES: We aimed to compare bare-metal stents (BMS), durable-polymer everolimus-eluting stents (DP-EES), and abluminal biodegradable-polymer sirolimus-eluting stents (ABP-SES) in the bifurcation model setup; RESULTS: Culotte stenting demonstrated more thrombogenicity at the proximal main branch (MB) with DP-EES, side branch (SB) with BMS, and the bifurcation site irrespective of the stent type, while DK crush technique exhibited thrombogenicity only at SB with BMS and ABP-SES. OCT analysis revealed malapposition of DP-EES in the proximal MB with culotte stenting. Stent expansion was generally larger in ABP-SES than BMS and DP-EES UR - https://dx.doi.org/10.1002/ccd.30187 ER -