TY - BOOK AU - Lenka, Abhishek TI - Abnormalities in the white matter tracts in patients with Parkinson disease and psychosis SN - 0028-3878 PY - 2020/// KW - *Brain/pa [Pathology] KW - *Parkinson Disease/pa [Pathology] KW - *Psychotic Disorders/pa [Pathology] KW - *White Matter/pa [Pathology] KW - Aged KW - Cross-Sectional Studies KW - Diffusion Tensor Imaging KW - Female KW - Humans KW - Male KW - Middle Aged KW - Parkinson Disease/co [Complications] KW - Psychotic Disorders/et [Etiology] KW - MedStar Washington Hospital Center KW - Neurology KW - Comment KW - Journal Article N1 - Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006 N2 - CONCLUSION: This study provides novel insights into the putative role of WM tract abnormalities in the pathogenesis of PD-P by demonstrating significant alterations in several WM tracts. Additional longitudinal studies are warranted to confirm the findings of our research. Copyright (c) 2020 American Academy of Neurology; METHODS: This cross-sectional study involved 48 PD-NP and 42 PD-P who were matched for age, sex, and education. Tract-based spatial statistics (TBSS) was used to compare several DTI metrics from the diffusion-weighted MRIs obtained through a 3-Tesla scanner. A set of neuropsychological tests was used for the cognitive evaluation of all patients; OBJECTIVE: The objective of the current study was to compare the microstructural integrity of the white matter (WM) tracts in patients having Parkinson disease (PD) with and without psychosis (PD-P and PD-NP) through diffusion tensor imaging (DTI); RESULTS: The severity and stage of PD were not statistically different between the groups. The PD-P group performed poorly in all the neuropsychological domains compared with the PD-NP group. TBSS analysis revealed widespread patterns of abnormality in the fractional anisotropy (FA) in the PD-P group, which also correlated with some of the cognitive scores. These tracts include inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, right parieto-occipital WM, body of the corpus callosum, and corticospinal tract UR - https://dx.doi.org/10.1212/WNL.0000000000009363 ER -