TY  - BOOK
AU  - Burman, Kenneth D
TI  - Thyrotropin isoforms: implications for thyrotropin analysis and clinical practice. [Review]
SN  - 1050-7256
PY  - 2014///
KW  - *Hypothyroidism/di [Diagnosis]
KW  - *Thyroid Function Tests
KW  - *Thyrotropin/an [Analysis]
KW  - Humans
KW  - Hypothyroidism/bl [Blood]
KW  - Immunoassay
KW  - Protein Isoforms
KW  - Thyrotropin/bl [Blood]
KW  - MedStar Washington Hospital Center
KW  - Medicine/Endocrinology
KW  - Journal Article
KW  - Research Support, N.I.H., Extramural
KW  - Research Support, Non-U.S. Gov't
KW  - Review
N1  - Available online from MWHC library: August 2000 - present, Available in print through MWHC library: 1999 - 2006
N2  - Serum thyrotropin (TSH) is considered the single most sensitive and specific measure of thyroid function in the general population owing to its negative logarithmic association with free triiodothyronine and free thyroxine concentrations. It is therefore often the test of choice for screening, diagnosis, and monitoring of primary hypothyroidism. Serum TSH concentrations can be analyzed quantitatively using third-generation immunoassays, whereas its bioactivity can be measured by TSH activity assays in cell culture. Theoretically, if serum TSH concentrations are directly related to TSH activity, the two tests should yield comparable results. However, on occasion, the results are discordant, with serum concentrations being higher than TSH biological activity. This review focuses on the dissociation between the clinical state and serum TSH concentrations and addresses clinically important aspects of TSH analysis
UR  - http://dx.doi.org/10.1089/thy.2013.0119
ER  -