TY  - BOOK
AU  - Calhoun, Darren
AU  - Howard, Barbara V
TI  - Cardiac geometry and function in diabetic or prediabetic adolescents and young adults: the Strong Heart Study
SN  - 0149-5992
PY  - 2011///
KW  - *Diabetes Mellitus/pp [Physiopathology]
KW  - *Prediabetic State/pp [Physiopathology]
KW  - Adolescent
KW  - Adult
KW  - Diabetes Mellitus/ep [Epidemiology]
KW  - Echocardiography
KW  - Female
KW  - Hemodynamics
KW  - Humans
KW  - Hypertension/ep [Epidemiology]
KW  - Hypertension/et [Etiology]
KW  - Hypertrophy, Left Ventricular/ep [Epidemiology]
KW  - Hypertrophy, Left Ventricular/et [Etiology]
KW  - Male
KW  - Prediabetic State/ep [Epidemiology]
KW  - Ventricular Function, Left/ph [Physiology]
KW  - Young Adult
KW  - MedStar Health Research Institute
KW  - Journal Article
KW  - Research Support, N.I.H., Extramural
N1  - Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006
N2  - CONCLUSIONS: In a population of adolescents and young adults, DM is independently associated with early unfavorable cardiovascular phenotype characterized by increased left ventricular mass, concentric geometry, and early preclinical systolic and diastolic dysfunction; early cardiovascular alterations are also present in participants with prediabetes; OBJECTIVE: The aim of this study was to evaluate whether diabetes (DM) and impaired fasting glucose (IFG) were associated with early alterations in left ventricular geometry and function in a large population of adolescents and young adults independently of major confounders; RESEARCH DESIGN AND METHODS: We analyzed echocardiographic data of 1,624 14- to 39-year-old participants (mean age 26.6 +/- 7.7 years; 57% female) without prevalent cardiovascular disease from the fourth Strong Heart Study examination; 179 (11%) participants had DM and 299 (18%) had IFG; RESULTS: Participants with DM and IFG were older and more often obese and hypertensive than participants with normal fasting glucose (NFG) (all P < 0.05). After adjustment for age, sex, systolic blood pressure, and body fat, diabetic and IFG participants had higher left ventricular mass index than those with NFG (41.5 +/- 8.7 and 39.6 +/- 9.2 vs. 35.6 +/- 7.8 g/m(2.7)) and reduced stress-corrected midwall shortening (98 +/- 8.6 and 99 +/- 7.5 vs. 101 +/- 8.5%; all P < 0.05). The prevalence of left ventricular hypertrophy was higher in DM (20%) and IFG (17%) than in NFG participants (12%; P < 0.05). Compared with the other groups, DM was also associated with higher prevalence of inappropriate left ventricular mass, concentric geometry, and more diastolic abnormalities independently of covariates (all P < 0.05)
UR  - http://dx.doi.org/10.2337/dc11-0191
ER  -