TY  - BOOK
AU  - Desale, Sameer
AU  - Ghabra, Shadin 
AU  - Sugarbaker, Paul H
TI  - Clinical and Histopathologic Features of 35 Patients Treated for Colorectal Peritoneal Metastases Who Survived 5 Years
SN  - 0012-3706
PY  - 2023///
KW  - IN PROCESS -- NOT YET INDEXED
KW  - MedStar Health Research Institute
KW  - Washington Cancer Institute
KW  - MedStar General Surgery Residency
KW  - MedStar Georgetown University Hospital/MedStar Washington Hospital Center
KW  - Journal Article
N1  - Available online from MWHC library: 1997 - present, Available in print through MWHC library: 1999 - 2006
N2  - BACKGROUND: Currently, patients with a limited extent of peritoneal metastases from colon and rectal cancer are treated by cytoreductive surgery combined with perioperative chemotherapy performed at experienced centers; CONCLUSIONS: The tumor biology as revealed by lymph node status and tumor differentiation plus extent of disease as measured by the response to neoadjuvant chemotherapy, peritoneal cancer index and no visible residual disease indicated a favorable outcome. See Video Abstract at http://links.lww.com/DCR/C62. Copyright © The ASCRS 2023; DESIGN: This is a retrospective review of a prospective database; LIMITATIONS: The study was limited by the retrospective nature, by unmeasured confounders, and data from a single institution; MAIN OUTCOME MEASURES: The primary outcomes measured were the clinical-, histologic- and treatment-related features that had an impact on 5-year survival; OBJECTIVE: To study and statistically evaluate features that may impact on survival of 5 years or more. These data are used in the risk/benefit analyses performed by the multidisciplinary team; PATIENTS: All patients who had biopsy-proven colon or rectal peritoneal metastases treated by systemic chemotherapy, complete cytoreductive surgery and perioperative surgery; RESULTS: From 131 patients who had a complete cytoreduction, 35 patients (26.7%) were identified as 5-year survivors. Median survival was 27 months. There were 16 males. Median age was 50.5 with a range of 25 to 80. By univariant analysis, an absence of lymph node involvement at the time of primary colorectal cancer resection (HR 1.899 (1.064, 3.388) p = 0.03), complete or near complete response to neoadjuvant chemotherapy (HR 0.251 (0.092, 0.684) p = 0.007), peritoneal cancer index <=17 (HR 0.509 (0.329, 0.788) p = 0.002), complete visible resection of disease indicated by completeness of cytoreduction score of 0 (HR 0.412 (0.224, 0.756) p = 0.004) and well-differentiated tumor (HR 0.34 (0.157, 0.737) p = 0.006) were significantly associated with 5 years or greater survival; SETTINGS: Single institution study at an academic center
UR  - https://dx.doi.org/10.1097/DCR.0000000000002448
ER  -