TY  - BOOK
AU  - Basyal, Binaya 
AU  - Oates, Connor 
AU  - Smith, Alex 
TI  - SGLT2 inhibitors reduce sudden cardiac death risk in heart failure: Meta-analysis of randomized clinical trials
SN  - 1045-3873
PY  - 2023///
KW  - *Atrial Fibrillation
KW  - *Diabetes Mellitus, Type 2
KW  - *Heart Failure
KW  - *Sodium-Glucose Transporter 2 Inhibitors
KW  - Atrial Fibrillation/co [Complications]
KW  - Death, Sudden, Cardiac/ep [Epidemiology]
KW  - Death, Sudden, Cardiac/et [Etiology]
KW  - Death, Sudden, Cardiac/pc [Prevention & Control]
KW  - Heart Failure/co [Complications]
KW  - Heart Failure/di [Diagnosis]
KW  - Heart Failure/dt [Drug Therapy]
KW  - Humans
KW  - Prospective Studies
KW  - Randomized Controlled Trials as Topic
KW  - Sodium-Glucose Transporter 2 Inhibitors/ae [Adverse Effects]
KW  - Automated
KW  - MedStar Washington Hospital Center
KW  - Cardiovascular Disease Fellowship
KW  - Journal Article
N1  - Available online through MWHC library: 2007 -2010, Available in print through MWHC library: 1999 - 2006
N2  - CONCLUSION: SGLT2i therapy is associated with a reduced risk of SCD in patients with heart failure receiving contemporary medical therapy. Prospective trials are needed to determine the long-term impact of SGLT2i therapy on atrial and ventricular arrhythmias. Copyright © 2023 Wiley Periodicals LLC; INTRODUCTION: Multiple randomized controlled trials have demonstrated sodium-glucose cotransporter-2 inhibitors (SGLT2i) decrease the composite endpoint of cardiovascular death or heart failure hospitalizations in all heart failure patients. It is uncertain whether SGLT2i impacts the risk of sudden cardiac death in patients with heart failure; METHODS: A comprehensive search was performed to identify relevant data published before August 28, 2022. Trials were included if: (1) all patients had clinical heart failure (2) SGLT2i and placebo were compared (3) all patients received conventional medical therapy and (4) reported outcomes of interest (sudden cardiac death [SCD], ventricular arrhythmias, atrial arrhythmias); RESULTS: SCD was reported in seven of the eleven trials meeting selection criteria: 10 796 patients received SGLT2i and 10 796 received placebo. SGLT2i therapy was associated with a significant reduction in the risk of SCD (risk ratios [RR]: 0.68; 95% confidence intervals [CI]: 0.48-0.95; p = .03; I2 = 0%). Absent dedicated rhythm monitoring, there were no significant differences in the incidence of sustained ventricular arrhythmias not associated with SCD (RR: 1.03; 95% CI: 0.83-1.29; p = .77; I2 = 0%) or atrial arrhythmias (RR: 0.91; 95% CI: 0.77-1.09; p = .31; I2 = 29%) between patients receiving an SGLT2i versus placebo
UR  - https://dx.doi.org/10.1111/jce.15894
ER  -