P-REALITY X: A Real-World Analysis of Palbociclib Plus an Aromatase Inhibitor in HR+/HER2- Metastatic Breast Cancer-A Podcast. 

 -  2023 
<br/><br/> Stringent enrollment criteria can limit the diversity of patient populations in clinical trials and, consequently, the generalizability of clinical trial data to real-world clinical practice. In this podcast, we discuss how real-world data in heterogeneous patient populations can complement clinical trial data in informing treatment decision making for patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) metastatic breast cancer. Specifically, our focus is on P-REALITY X, an observational retrospective analysis that was recently published in npj Breast Cancer. P-REALITY X used real-world data from the Flatiron database to compare the effectiveness of palbociclib plus an aromatase inhibitor versus an aromatase inhibitor alone as first-line treatment for patients with HR+/HER2- metastatic breast cancer. After stabilized inverse probability treatment weighting to control for observed confounders, both overall survival and real-world progression-free survival were significantly prolonged with palbociclib plus an aromatase inhibitor versus an aromatase inhibitor alone. Furthermore, overall survival and real-world progression-free survival benefits were observed across most subgroups examined. We discuss the clinical implications of P-REALITY X data, including how these results add to data from prior randomized clinical trials and real-world studies in supporting the use of first-line palbociclib plus an aromatase inhibitor as a standard-of-care treatment for patients with HR+/HER2- metastatic breast cancer. We also provide an example of how to integrate and describe key information about the P-REALITY X study in plain language when discussing palbociclib as a therapeutic option with patients. Copyright © 2023. The Author(s). 
<br/><br/><br/>English 
<br/><br/><label>ISSN: </label>1776-2596 
<br/><br/><label>Standard No.: </label>10.1007/s11523-023-00968-4 [doi] 10.1007/s11523-023-00968-4 [pii] PMC10192186 [pmc] 
<br/><br/><label>Subjects--Topical Terms: </label><br/>*Breast Neoplasms<br/>Antineoplastic Combined Chemotherapy Protocols/pd [Pharmacology]<br/>Antineoplastic Combined Chemotherapy Protocols/tu [Therapeutic Use]<br/>Aromatase Inhibitors/pd [Pharmacology]<br/>Aromatase Inhibitors/tu [Therapeutic Use]<br/>Breast Neoplasms/pa [Pathology]<br/>Female<br/>Humans<br/>Receptor, ErbB-2/me [Metabolism]<br/>Retrospective Studies--Automated
<br/><br/><label>Subjects--Geographic Terms: </label><br/>Washington Cancer Institute
<br/><br/><label>Index Terms--Function: </label><br/>Letter<br/>Observational Study