TY  - BOOK
AU  - Feghali, Maisa N
AU  - Miodovnik, Menachem
TI  - Fetal development in women with diabetes: imprinting for a life-time?
SN  - 1476-4954
KW  - *Diabetes Mellitus, Type 1/co [Complications]
KW  - *Pregnancy in Diabetics
KW  - *Prenatal Exposure Delayed Effects
KW  - Absorptiometry, Photon
KW  - Adiposity
KW  - Birth Weight
KW  - Blood Glucose/an [Analysis]
KW  - Blood Pressure
KW  - Body Mass Index
KW  - Diabetes Mellitus, Type 1/bl [Blood]
KW  - Fasting
KW  - Feasibility Studies
KW  - Female
KW  - Fetal Macrosomia
KW  - Follow-Up Studies
KW  - Glucose Tolerance Test
KW  - Hemoglobin A, Glycosylated/an [Analysis]
KW  - Humans
KW  - Insulin/bl [Blood]
KW  - Male
KW  - Pilot Projects
KW  - Pregnancy
KW  - Pregnancy Trimesters
KW  - Prospective Studies
KW  - Young Adult
KW  - MedStar Health Research Institute
KW  - MedStar Washington Hospital Center
KW  - Obstetrics and Gynecology/Maternal-Fetal Medicine
KW  - Journal Article
KW  - Randomized Controlled Trial
KW  - Research Support, N.I.H., Extramural
N1  - Available online through MWHC library: 2013 to the present
N2  - CONCLUSION: The hyperglycemic intrauterine environment is associated with short-term morbidity, manifested as asymmetric LGA (the "fat" baby). In addition, increasing level of maternal hyperglycemia during pregnancy is associated with increased adiposity and elevated fasting glucose in the young adult offspring; METHODS: We report findings from a feasibility study on 19 young adults, born to mothers with type 1 diabetes. Long-term follow-up of the offspring in young adulthood included: oral glucose tolerance test, body mass index (BMI), dual X-ray absorptiometry, and blood pressure (BP). We report z-BMI and z-BP to account for varying gender and age; OBJECTIVE: To test the hypothesis that fetal exposure to a hyperglycemic intrauterine environment in women with type 1 diabetes is associated with asymmetrically distributed excessive fetal growth and imprinting consistent with adverse health issues later in life; RESULTS: The young adults born to women with diabetes averaged 19.9 years at follow-up; 37% were female, and 21% African American. Maternal glycohemoglobin A(1) concentration in the 2nd trimester was 9.2% for offspring born with asymmetric LGA and 7.5% for those born with symmetric LGA or AGA. There was significant correlation between maternal glucose control during pregnancy and fasting glucose, z-BMI and z-systolic BP in the young adults
UR  - http://dx.doi.org/10.3109/14767058.2012.626921
ER  -