TY  - BOOK
AU  - Hernaez, Ruben
TI  - Genetic factors associated with the presence and progression of nonalcoholic fatty liver disease: a narrative review. [Review]
SN  - 0210-5705
KW  - *Fatty Liver/ge [Genetics]
KW  - Disease Progression
KW  - Genome-Wide Association Study
KW  - Humans
KW  - MedStar Washington Hospital Center
KW  - Medicine/Gastroenterology
KW  - Journal Article
KW  - Research Support, Non-U.S. Gov't
KW  - Review
N2  - Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world. Whereas insulin resistance and obesity are considered major risk factors for the development and progression of NAFLD, the genetic underpinnings are unclear. Before 2008, candidate gene studies based on prior knowledge of pathophysiology of fatty liver yielded conflicting results. In 2008, Romeo et al. published the first genome wide association study and reported the strongest genetic signal for the presence of fatty liver (PNPLA3, patatin-like phospholipase domain containing 3; rs738409). Since then, two additional genome wide scans were published and identified 9 additional genetic variants. Whereas these results shed light into the understanding of the genetics of NAFLD, most of associations have not been replicated in independent samples and, therefore, remain undetermined the significance of these findings. This review aims to summarize the understanding of genetic epidemiology of NAFLD and highlights the gaps in knowledge. Copyright  2011 Elsevier Espana, S.L. All rights reserved
UR  - http://dx.doi.org/10.1016/j.gastrohep.2011.08.002
ER  -