Dietary patterns are associated with disease risk among participants in the Women's Health Initiative Observational Study. 

<br/><br/>Available online from MWHC library: Sept 1928 - present (after 1 year) 
<br/><br/> Coronary heart disease (CHD) is the leading cause of death in women. A nested case-control study tested whether dietary patterns predicted CHD events among 1224 participants in the Women's Health Initiative-Observational Study (WHI-OS) with centrally confirmed CHD, fatal or nonfatal myocardial infarct compared to 1224 WHI-OS controls matched for age, enrollment date, race/ethnicity, and absence of CHD at baseline or follow-up. The first six principal components explained >75% of variation in dietary intakes and K-mean analysis based on these six components produced three clusters. Diet cluster 1 was rich in carbohydrate, vegetable protein, fiber, dietary vitamin K, folate, carotenoids, -linolenic acid [18:3(n-3)], linoleic acid [18:2(n-6)], and supplemental calcium and vitamin D. Diet cluster 2 was rich in total and animal protein, arachidonic acid [20:4(n-6)], DHA [22:6(n-3)], vitamin D, and calcium. Diet cluster 3 was rich in energy, total fat, and trans fatty acids (all P < 0.01). Conditional logistic regression analysis demonstrated diet cluster 1 was associated with lower CHD risk than diet cluster 2 (reference group) adjusted for smoking, education, and physical activity [OR = 0.79 (95% CI = 0.64, 0.99); P = 0.038]. This difference was not significant after adjustment for BMI and systolic blood pressure. Diet cluster 3 was associated with higher CHD risk than diet cluster 2 [OR = 1.28 (95% CI = 1.04, 1.57); P = 0.019], but this difference did not remain significant after adjustment for smoking, education, and physical activity. Within this WHI-OS cohort, distinct dietary patterns may be associated with subsequent CHD outcomes. 
<br/><br/><br/>English 
<br/><br/><label>ISSN: </label>0022-3166 
<br/><br/><label>Subjects--Topical Terms: </label><br/>*Coronary Disease/et [Etiology]<br/>*Diet/ae [Adverse Effects]<br/>*Food Habits<br/>*Women's Health<br/>Aged<br/>Aging<br/>Case-Control Studies<br/>Cluster Analysis<br/>Coronary Disease/ep [Epidemiology]<br/>Ethnic Groups<br/>Female<br/>Humans<br/>Logistic Models<br/>Middle Aged<br/>Odds Ratio<br/>Principal Component Analysis<br/>Risk Factors<br/>Women's Health/sn [Statistics & Numerical Data]
<br/><br/><label>Subjects--Geographic Terms: </label><br/>MedStar Health Research Institute
<br/><br/><label>Index Terms--Function: </label><br/>Journal Article<br/>Research Support, N.I.H., Extramural