TY  - BOOK
AU  - Howard, Barbara V
TI  - A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry
SN  - 1061-4036
KW  - *African Americans/ge [Genetics]
KW  - *Body Mass Index
KW  - *Obesity/ge [Genetics]
KW  - Case-Control Studies
KW  - Gene Frequency
KW  - Genetic Loci
KW  - Genetic Predisposition to Disease
KW  - Genome-Wide Association Study
KW  - Humans
KW  - Linkage Disequilibrium
KW  - Obesity/eh [Ethnology]
KW  - Polymorphism, Single Nucleotide
KW  - MedStar Health Research Institute
KW  - Journal Article
KW  - Meta-Analysis
KW  - Research Support, N.I.H., Extramural
KW  - Research Support, N.I.H., Intramural
KW  - Research Support, Non-U.S. Gov't
KW  - Research Support, U.S. Gov't, Non-P.H.S
N2  - Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one new locus at 5q33 (GALNT10, rs7708584, P = 3.4 x 10(-11)) and another at 7p15 when we included data from the GIANT consortium (MIR148A-NFE2L3, rs10261878, P = 1.2 x 10(-10)). We also found suggestive evidence of an association at a third locus at 6q16 in the African-ancestry sample (KLHL32, rs974417, P = 6.9 x 10(-8)). Thirty-two of the 36 previously established BMI variants showed directionally consistent effect estimates in our GWAS (binomial P = 9.7 x 10(-7)), five of which reached genome-wide significance. These findings provide strong support for shared BMI loci across populations, as well as for the utility of studying ancestrally diverse populations
UR  - http://dx.doi.org/10.1038/ng.2608
ER  -