Paravalvular regurgitation after transcatheter aortic valve replacement: diagnosis, clinical outcome, preventive and therapeutic strategies. [Review] 

<br/><br/>Available in print through MWHC library: 2002 - present 
<br/><br/> Paravalvular regurgitation is a common, potentially life-threatening complication of transcatheter aortic valve replacement. Previous studies report a 65%-94% rate of paravalvular leakage after transcatheter implantation, mostly of mild degree. The rate of significant (> +2) paravalvular regurgitation varies in large clinical trials, and is associated with worse clinical outcome. There is less agreement regarding the significance of mild regurgitation (grade 1+). There are anatomical and procedural correlates for paravalvular leak-most importantly, severe valve calcification, patient prosthetic mismatch, and device malposition. The following review details the current knowledge on paravalvular regurgitation after transcatheter aortic valve replacement, including diagnosis, correlates, clinical outcome, preventive and therapeutic strategies related to this complication. Copyright  2013. Published by Elsevier Inc. 
<br/><br/><br/>English 
<br/><br/><label>ISSN: </label>1878-0938 
<br/><br/><label>Subjects--Topical Terms: </label><br/>*Aortic Valve Insufficiency/et [Etiology]<br/>*Aortic Valve Stenosis/th [Therapy]<br/>*Aortic Valve/pp [Physiopathology]<br/>*Cardiac Catheterization/ae [Adverse Effects]<br/>*Heart Valve Prosthesis Implantation/ae [Adverse Effects]<br/>*Hemodynamics<br/>Aortic Valve Insufficiency/di [Diagnosis]<br/>Aortic Valve Insufficiency/pc [Prevention & Control]<br/>Aortic Valve Insufficiency/pp [Physiopathology]<br/>Aortic Valve Insufficiency/th [Therapy]<br/>Aortic Valve Stenosis/pp [Physiopathology]<br/>Cardiac Catheterization/is [Instrumentation]<br/>Heart Valve Prosthesis<br/>Heart Valve Prosthesis Implantation/is [Instrumentation]<br/>Heart Valve Prosthesis Implantation/mt [Methods]<br/>Humans<br/>Prosthesis Design<br/>Severity of Illness Index<br/>Time Factors<br/>Treatment Outcome
<br/><br/><label>Subjects--Geographic Terms: </label><br/>MedStar Heart & Vascular Institute
<br/><br/><label>Index Terms--Function: </label><br/>Journal Article<br/>Review