TY  - BOOK
AU  - Barbash, Israel M
AU  - Loh, Joshua P
AU  - Waksman, Ron
TI  - The current status of drug-coated balloons in percutaneous coronary and peripheral interventions. [Review]
SN  - 1774-024X
KW  - *Clinical Trials as Topic
KW  - *Coronary Artery Disease/th [Therapy]
KW  - *Drug-Eluting Stents
KW  - *Percutaneous Coronary Intervention
KW  - Angioplasty, Balloon, Coronary/mt [Methods]
KW  - Animals
KW  - Coronary Restenosis/th [Therapy]
KW  - Humans
KW  - MedStar Heart & Vascular Institute
KW  - Journal Article
KW  - Review
N2  - Through continued innovation, percutaneous treatment of coronary and peripheral stenoses has evolved rapidly since balloon angioplasty was first introduced three decades ago. Significant advances were made with the introduction of bare metal stents and subsequently drug-eluting stents, which expanded the possibility of successful revascularisation in complicated lesions. Despite these advantages, efforts are still ongoing to improve patient outcomes further. In recent years, drug-coated balloons have emerged as an exciting technology developed to overcome the limitations faced by drug-eluting stents, such as stent thrombosis and dependency on prolonged dual antiplatelet therapy, and may prove efficacious in complex subsets such as small vessels and diffuse lesions where stent results are suboptimal. Several drug-coated balloons developed for coronary and peripheral applications were evaluated recently in preclinical and clinical studies with encouraging results. Drug-coated balloons have proven effective in treating in-stent restenosis; however, there is accumulating evidence on their utility in other clinical scenarios. We present a timely review of the mechanisms of action, key preclinical studies, emerging clinical indications, current clinical trial results, and future perspectives of this novel drug-coated balloon technology as it seeks to establish its role in percutaneous intervention
UR  - http://dx.doi.org/10.4244/EIJV9I8A164
ER  -