TY  - BOOK
AU  - Minha, Sa'ar
AU  - Waksman, Ron
TI  - Evaluation of the Edwards Lifesciences SAPIEN transcatheter heart valve. [Review]
SN  - 1743-4440
KW  - *Aortic Valve Stenosis/su [Surgery]
KW  - *Heart Valve Prosthesis
KW  - *Prosthesis Implantation/mt [Methods]
KW  - Aortic Valve/su [Surgery]
KW  - Equipment Design
KW  - Equipment Failure Analysis
KW  - Evidence-Based Medicine
KW  - Humans
KW  - Technology Assessment, Biomedical
KW  - MedStar Heart & Vascular Institute
KW  - Journal Article
KW  - Research Support, Non-U.S. Gov't
KW  - Review
N2  - Severe aortic stenosis is a common valvular disease and is associated with both morbidity and mortality. Surgical aortic valve replacement was the only available therapeutic option until technological advances allowed for the development of a transcatheter heart valve system. The first available THV was the Edwards SAPIEN. The merits of this system in terms of safety and efficacy were explored in the pivotal Placement of AoRTic TraNscathetER (PARTNER) randomized trial whose results then led to the approval of this device for commercial use in the US. The valve is now indicated for inoperable patients and may be considered an alternative for surgery for high-risk patients. Two successive models, the XT and more recently the S3, were developed with the intent to improve procedural outcomes. In this article, the SAPIEN transcatheter heart valve family is described in terms of technology, scientific data and future directions
UR  - http://dx.doi.org/10.1586/17434440.2014.947272
ER  -