Developing trends in the intestinal transplant waitlist.
Available online from MWHC library: May 2001 - present
The United Network for Organ Sharing database was examined for trends in the intestinal transplant (ITx) waitlist from 1993 to 2012, dividing into listings for isolated ITx versus liver-intestine transplant (L-ITx). Registrants added to the waitlist increased from 59/year in 1993 to 317/year in 2006, then declined to 124/year in 2012; Spline modeling showed a significant change in the trend in 2006, p<0.001. The largest group of registrants, <1year of age, determined the trend for the entire population; other pediatric age groups remained stable, adult registrants increased until 2012. The largest proportion of new registrants were for L-ITx, compared to isolated ITx; the change in the trend in 2006 for L-ITx was highly significant, p<0.001, but not isolated ITx, p=0.270. New registrants for L-ITx, <1year of age, had the greatest increase and decrease. New registrants for isolated ITx remained constant in all pediatric age groups. Waitlist mortality increased to a peak around 2002, highest for L-ITx, in patients <1year of age and adults. Deaths among all pediatric age groups awaiting L-ITx have decreased; adult L-ITx deaths have dropped less dramatically. Improved care of infants with intestinal failure has led to reduced referrals for L-ITx. � Copyright 2014 The American Society of Transplantation and the American Society of Transplant Surgeons.
English
1600-6135
*Intestines/tr [Transplantation] *Mortality/td [Trends] *Organ Transplantation/mo [Mortality] *Organ Transplantation/sn [Statistics & Numerical Data] *Tissue and Organ Procurement/sn [Statistics & Numerical Data] *Waiting Lists/mo [Mortality] Adolescent Adult Age Factors Child Child, Preschool Female Follow-Up Studies Humans Infant Infant, Newborn Male Prognosis Survival Rate Young Adult
MedStar Health Research Institute MedStar Washington Hospital Center
Surgery/Transplantation
Journal Article Research Support, U.S. Gov't, P.H.S.