TY - BOOK AU - Cejudo-Tejeda, Marco AU - Garcia-Garcia, Hector M AU - Hideo-Kajita, Alexandre AU - Ho, Gavin AU - Kuku, Kayode AU - Soud, Mohamad AU - Waksman, Ron TI - Usefulness of skeletal muscle area detected by computed tomography to predict mortality in patients undergoing transcatheter aortic valve replacement: a meta-analysis study. [Review] SN - 1569-5794 PY - 2019/// KW - *Aortic Valve Stenosis/su [Surgery] KW - *Aortic Valve/su [Surgery] KW - *Geriatric Assessment/mt [Methods] KW - *Muscle, Skeletal/dg [Diagnostic Imaging] KW - *Sarcopenia/dg [Diagnostic Imaging] KW - *Tomography, X-Ray Computed KW - *Transcatheter Aortic Valve Replacement/mo [Mortality] KW - Age Factors KW - Aged KW - Aged, 80 and over KW - Aortic Valve Stenosis/dg [Diagnostic Imaging] KW - Aortic Valve Stenosis/mo [Mortality] KW - Aortic Valve Stenosis/pp [Physiopathology] KW - Aortic Valve/dg [Diagnostic Imaging] KW - Aortic Valve/pp [Physiopathology] KW - Female KW - Humans KW - Male KW - Predictive Value of Tests KW - Risk Assessment KW - Risk Factors KW - Sarcopenia/mo [Mortality] KW - Time Factors KW - Transcatheter Aortic Valve Replacement/ae [Adverse Effects] KW - Treatment Outcome KW - MedStar Heart & Vascular Institute KW - Journal Article KW - Review N2 - Measures of sarcopenia, such as low muscle mass measured from the readily available preoperative computed tomography (CT) images, have been recently suggested as a predictor of outcomes in patients undergoing transcatheter aortic valve replacement (TAVR). However, results of these studies are variable and, therefore, we performed a systematic review of current literature to evaluate sarcopenia as a predictor of outcome post TAVR. The search was carried out in electronic databases between 2008 and 2018. We identified studies that reported CT-derived skeletal muscle area (SMA) and survival outcomes post TAVR. Studies were evaluated for the incidence of early (<= 30 days) and late all-cause mortality (> 30 days) post TAVR. Eight studies with 1881 patients were included (mean age of 81.8 years +/- 12, 55.9% men). Mean body mass index was (28.2 kg/m2 +/- 1.1), mean Society of Thoracic Surgeons risk score (7.0 +/- 0.6), and mean albumin level was (3.8 g/dL +/- 0.1). Higher SMA was associated with lower long-term mortality [odds ratio (OR) 0.49, 95% confidence interval (CI) 0.28-0.83, p = 0.049], compared with low SMA. Also, higher SMA was associated with lower early mortality but was not statistically significant (OR 0.72; 95% CI 0.44-1.18; p = 0.285). CT-derived SMA provides value in predicting post-TAVR long-term outcomes for patients undergoing TAVR. This is a simple risk assessment tool that may help in making treatment decisions and help identifying and targeting high-risk patients with interventions to improve muscle mass prior to and following the procedures UR - https://dx.doi.org/10.1007/s10554-019-01582-0 ER -