Treatment of refractory delayed onset heparin-induced thrombocytopenia after thoracic endovascular aortic repair with intravenous immunoglobulin (IVIG). 

 -  2017 
<br/><br/> Delayed onset heparin induced thrombocytopenia (HIT), is characterized by a late nadir due to persistent platelet-activating IgG antibodies. It typically begins or worsens 5 or more days after heparin is discontinued with complications such as thrombosis up to 3 weeks after exposure to heparin.1-3 In 50% of cases, the platelet count can decrease to very low numbers (<20 000/muL), which is not usual for typical HIT. Here we report 2 cases of post-operative delayed onset HIT manifesting as severe thrombocytopenia that persisted despite cessation of heparin and initiation of argatroban. Key Clinical Question: Is intravenous immunoglulin beneficial in severe refractory delayed-onset HIT? 
<br/><br/><br/>English 
<br/><br/><label>ISSN: </label>2475-0379 
<br/><br/><label>Standard No.: </label>10.1002/rth2.12009 [doi] PMC6058197 [pmc] S2475-0379(22)02151-3 [pii] 
<br/><br/><label>Subjects--Geographic Terms: </label><br/>MedStar Washington Hospital Center
<br/><br/><label>Index Terms--Occupation: </label><br/>Hematology/Oncology<br/>Medicine/Internal Medicine
<br/><br/><label>Index Terms--Function: </label><br/>Case Reports