TY  - BOOK
AU  - Cruz, Allan L
AU  - DeStefano, Christin B
AU  - Doucette, Kimberley
AU  - Fitzpatrick, Kelly
AU  - Jain, Natasha A
AU  - Malkovska, Vera
TI  - Treatment of refractory delayed onset heparin-induced thrombocytopenia after thoracic endovascular aortic repair with intravenous immunoglobulin (IVIG)
SN  - 2475-0379
PY  - 2017///
KW  - MedStar Washington Hospital Center
KW  - Hematology/Oncology
KW  - Medicine/Internal Medicine
KW  - Case Reports
N2  - Delayed onset heparin induced thrombocytopenia (HIT), is characterized by a late nadir due to persistent platelet-activating IgG antibodies. It typically begins or worsens 5 or more days after heparin is discontinued with complications such as thrombosis up to 3 weeks after exposure to heparin.1-3 In 50% of cases, the platelet count can decrease to very low numbers (<20 000/muL), which is not usual for typical HIT. Here we report 2 cases of post-operative delayed onset HIT manifesting as severe thrombocytopenia that persisted despite cessation of heparin and initiation of argatroban. Key Clinical Question: Is intravenous immunoglulin beneficial in severe refractory delayed-onset HIT?
UR  - https://dx.doi.org/10.1002/rth2.12009
ER  -