Antisynthetase Syndrome With Paraneoplastic Antibodies. 

 -  2023 
<br/><br/> Antisynthetase syndrome (ASyS) is an uncommon systemic autoimmune disorder characterized by the presence of autoantibodies targeting aminoacyl-transfer RNA (tRNA) synthetase. The syndrome displays a diverse range of clinical manifestations affecting multiple organs, thereby posing a diagnostic challenge. In this report, we present an unusual case of a patient diagnosed with ASyS, displaying positive anti-PL-12 antibodies along with paraneoplastic antibodies. To the best of our knowledge, this is the first documented case in the existing literature describing ASyS with the presence of anti-PL-12 antibodies and concomitant paraneoplastic antibodies in the context of ductal carcinoma in situ. Copyright © 2023, Pokharel et al. 
<br/><br/><br/>English 
<br/><br/><label>ISSN: </label>2168-8184 
<br/><br/><label>Standard No.: </label>10.7759/cureus.40354 [doi] PMC10290814 [pmc] 
<br/><br/><label>Subjects--Topical Terms: </label>--Automated
<br/><br/><label>Subjects--Geographic Terms: </label><br/>MedStar Union Memorial Hospital
<br/><br/><label>Index Terms--Occupation: </label><br/>Internal Medicine Residency
<br/><br/><label>Index Terms--Function: </label><br/>Case Reports