TY  - BOOK
AU  - Taylor, Allen J
TI  - The perimenopausal atherosclerosis transition: relationships between calcified and noncalcified coronary, aortic, and carotid atherosclerosis and risk factors and hormone levels
SN  - 1072-3714
PY  - 2012///
KW  - *Aorta/pa [Pathology]
KW  - *Carotid Arteries/pa [Pathology]
KW  - *Coronary Vessels/pa [Pathology]
KW  - *Hormones/bl [Blood]
KW  - *Perimenopause/ph [Physiology]
KW  - *Vascular Calcification/pa [Pathology]
KW  - Atherosclerosis/ep [Epidemiology]
KW  - Atherosclerosis/pa [Pathology]
KW  - Cardiovascular Diseases/ep [Epidemiology]
KW  - Cardiovascular Diseases/pa [Pathology]
KW  - Cross-Sectional Studies
KW  - Female
KW  - Follicle Stimulating Hormone/bl [Blood]
KW  - Humans
KW  - Middle Aged
KW  - Plaque, Atherosclerotic/pa [Pathology]
KW  - Risk Factors
KW  - Sex Hormone-Binding Globulin/an [Analysis]
KW  - Testosterone/bl [Blood]
KW  - Tomography, X-Ray Computed
KW  - Ultrasonography
KW  - MedStar Heart & Vascular Institute
KW  - Journal Article
KW  - Research Support, U.S. Gov't, Non-P.H.S
N1  - Available online from MWHC library: November 2000 - present
N2  - CONCLUSIONS: Coronary, aortic, and carotid arterial plaque is prevalent in perimenopausal women without cardiac symptoms. The assessment of perimenopausal hormone status was not independently associated with subclinical atherosclerosis beyond standard cardiovascular risk factors; METHODS: The Assessment of the Transition of Hormonal Evaluation with Noninvasive Imaging of Atherosclerosis was a prospective substudy of the Prospective Army Coronary Calcium project. We screened 126 asymptomatic perimenopausal women (mean age, 50 y) using contrast-enhanced CT angiography (multidetector CT) and carotid ultrasound. Women had coronary calcium data from 5 to 10 years earlier. The measures included cardiovascular risk factors, serum hormone levels, 64-slice multidetector CT, and carotid ultrasound; OBJECTIVE: Women of perimenopause age experience an upward transition of cardiovascular risk possibly in association with changing hormonal status. We examined the cross-sectional relationships between the atherosclerotic plaque within the coronary and carotid arteries and aorta and the menopausal hormone levels among asymptomatic perimenopausal women; RESULTS: The prevalence of any coronary plaque was 35.5%. The prevalence of noncalcified plaque was 30.2%, and noncalcified plaque was the only manifestation of coronary artery disease in 10.7%. Markers of androgenicity (increased free testosterone and reduced sex hormone-binding globulin) were associated with an increased extent of calcified and noncalcified coronary artery plaque and aortic plaque. However, these relationships were not independent of cardiovascular risk factors. Follicle-stimulating hormone was directly associated with the number of aortic plaques. The levels of estrogen hormones were unrelated to plaque presence or extent
UR  - http://dx.doi.org/10.1097/gme.0b013e318221bc8d
ER  -