TY  - BOOK
AU  - Weissman, Neil J
TI  - Percutaneous mitral valve repair in the initial EVEREST cohort: evidence of reverse left ventricular remodeling
SN  - 1941-9651
PY  - 2013///
KW  - *Cardiac Catheterization
KW  - *Heart Ventricles/pp [Physiopathology]
KW  - *Mitral Valve Annuloplasty
KW  - *Mitral Valve Insufficiency/th [Therapy]
KW  - *Ventricular Dysfunction, Left/pp [Physiopathology]
KW  - *Ventricular Function, Left
KW  - *Ventricular Remodeling
KW  - Aged
KW  - Aged, 80 and over
KW  - Analysis of Variance
KW  - Canada
KW  - Cardiac Catheterization/is [Instrumentation]
KW  - Cardiac Catheters
KW  - Equipment Design
KW  - Female
KW  - Heart Ventricles/us [Ultrasonography]
KW  - Hemodynamics
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - Mitral Valve Annuloplasty/is [Instrumentation]
KW  - Mitral Valve Insufficiency/pp [Physiopathology]
KW  - Mitral Valve Insufficiency/us [Ultrasonography]
KW  - Prospective Studies
KW  - Recovery of Function
KW  - Severity of Illness Index
KW  - Stroke Volume
KW  - Time Factors
KW  - Treatment Outcome
KW  - United States
KW  - Ventricular Dysfunction, Left/us [Ultrasonography]
KW  - MedStar Heart & Vascular Institute
KW  - Clinical Trial, Phase II
KW  - Journal Article
KW  - Multicenter Study
KW  - Randomized Controlled Trial
KW  - Research Support, Non-U.S. Gov't
N2  - BACKGROUND: Percutaneous repair of mitral regurgitation (MR) permits examination of the effect of MR reduction without surgery and cardiopulmonary bypass on left ventricular (LV) dimensions and function. The goal of this analysis was to determine the extent of reverse remodeling at 12 months after successful percutaneous reduction of MR with the MitraClip device; CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifiers: NCT00209339, NCT00209274; CONCLUSIONS: Patients with pre-existing LV dysfunction demonstrate reverse remodeling and improved LV ejection fraction after percutaneous mitral valve repair; METHODS AND RESULTS: Of 64 patients with 3 and 4+ MR who achieved acute procedural success after treatment with the MitraClip device, 49 patients had moderate or less MR at 12-month follow-up. Their baseline and 12-month echocardiograms were compared between the group with and without LV dysfunction. In patients with persistent MR reduction and pre-existing LV dysfunction, there was a reduction in LV wall stress, reduced LV end-diastolic volume, LV end-systolic volume and increase in LV ejection fraction in contrast to those with normal baseline LV function, who showed reduction in LV end-diastolic volume, LV wall stress, no 131223 in LV end-systolic volume, and a fall in LV ejection fraction
UR  - http://dx.doi.org/10.1161/CIRCIMAGING.112.000098
ER  -