TY  - BOOK
AU  - Torguson, Rebecca
AU  - Waksman, Ron
TI  - Short and long-term safety and efficacy of polymer-free vs. durable polymer drug-eluting stents. A comprehensive meta-analysis of randomized trials including 6178 patients. [Review]
SN  - 0021-9150
PY  - 2014///
KW  - *Drug-Eluting Stents/ae [Adverse Effects]
KW  - *Randomized Controlled Trials as Topic
KW  - Humans
KW  - Myocardial Infarction/mo [Mortality]
KW  - Polymers/ae [Adverse Effects]
KW  - Probucol/ad [Administration & Dosage]
KW  - Sirolimus/ad [Administration & Dosage]
KW  - Stents/ae [Adverse Effects]
KW  - Thrombosis/pc [Prevention & Control]
KW  - Treatment Outcome
KW  - MedStar Heart & Vascular Institute
KW  - Journal Article
KW  - Meta-Analysis
KW  - Research Support, Non-U.S. Gov't
KW  - Review
N2  - BACKGROUND: The efficacy and safety of polymer-free drug-eluting stents (DESs) in clinical practice is currently subject of debate; randomized trials (RCTs) conducted so far provided conflicting results or were underpowered to definitively address this question; we aimed to investigate the efficacy and safety profile of polymer-free vs. durable polymer DES by a comprehensive meta-analysis of RCTs; CONCLUSIONS: Polymer-free DESs are as safe and effective as durable polymer DES; however, there is no evidence of any additional benefits provided by this new technology. Copyright  2014 Elsevier Ireland Ltd. All rights reserved; METHODS: MEDLINE, Google Scholar, EMBASE and Cochrane databases were searched for RCTs comparing polymer-free to durable polymer DES. Safety endpoints at short-term (< 1 year) and long-term follow-up (>1-year) were: death, myocardial infarction (MI) and stent thrombosis (ST); main efficacy endpoints were: target lesion revascularization (TLR) and target vessel revascularization (TVR); RESULTS: Eight RCTs including 6178 patients were included. No significant differences in mortality were observed between polymer-free and durable polymer DESs at both short- and long-follow up (OR [95% CI] = 0.79 [0.58-1.08], p = 0.14; and 0.80 [0.58-1.10], p = 0.17 respectively); polymer free and durable polymer DESs provided comparable short and long-term MI rates; at short-term: OR [95% CI] = 1.13 [0.83-1.54], p = 0.44 and at long-term: OR [95% CI] = 1.27 [0.87-1.85], p = 0.22. Similarly, these two different devices proved equally effective in regards to ST, TLR and TVR over the short and long follow-up period
UR  - http://dx.doi.org/10.1016/j.atherosclerosis.2013.12.024
ER  -