The Role of Immunotherapy in Pancreatic Cancer. [Review]
Debnath, Dipanjan
MWHC Internal Medicine Residency
MBBS
Resident PGY 3
text
xx
2022
monographic
en
Pancreatic adenocarcinoma remains one of the most lethal cancers globally, with a significant need for improved therapeutic options. While the recent breakthroughs of immunotherapy through checkpoint inhibitors have dramatically changed treatment paradigms in other malignancies based on considerable survival benefits, this is not so for pancreatic cancer. Chemotherapies with modest benefits are still the cornerstone of advanced pancreatic cancer treatment. Pancreatic cancers are inherently immune-cold tumors and have been largely refractory to immunotherapies in clinical trials. Understanding and overcoming the current failures of immunotherapy through elucidating resistance mechanisms and developing novel therapeutic approaches are essential to harnessing the potential durable benefits of immune-modulating therapy in pancreatic cancer patients.
Available online through MWHC library: 2006 - present
English
*Adenocarcinoma
*Pancreatic Neoplasms
Humans
Immunologic Factors
Immunotherapy
Pancreatic Neoplasms/dt [Drug Therapy]
Pancreatic Neoplasms/pa [Pathology]
MedStar Washington Hospital Center
Internal Medicine Residency
1198-0052
https://dx.doi.org/10.3390/curroncol29100541
https://dx.doi.org/10.3390/curroncol29100541
Ovid MEDLINE(R)
221213