TY  - BOOK
AU  - Tefera, Eshetu
TI  - Opioid treatment of experimental pain activates nuclear factor-kappaB
SN  - 1551-7489
PY  - 2015///
KW  - *Analgesics, Opioid/tu [Therapeutic Use]
KW  - *Fentanyl/tu [Therapeutic Use]
KW  - *NF-kappa B/bl [Blood]
KW  - *Pain/dt [Drug Therapy]
KW  - Adult
KW  - Female
KW  - Follow-Up Studies
KW  - Healthy Volunteers
KW  - Humans
KW  - Injections, Intravenous
KW  - Male
KW  - Monocytes/de [Drug Effects]
KW  - Pain/bl [Blood]
KW  - Signal Transduction/de [Drug Effects]
KW  - MedStar Health Research Institute
KW  - Journal Article
KW  - Observational Study
KW  - Randomized Controlled Trial
KW  - Research Support, N.I.H., Extramural
KW  - Research Support, Non-U.S. Gov't
N2  - CONCLUSIONS: The combination of acute pain with opioids, as occurs in clinical situations, activates a key transcription factor involved in proinflammatory responses; DESIGN: NF-kappaB activation was compared within-subjects following four randomly ordered experimental sessions of opioid-only (intravenous fentanyl 1 mug/kg), painonly (cold-pressor), opioid + pain, and a resting condition; INTERVENTIONS: Following exposure to treatment (fentanyl administration and/or cold-pressor pain), blood samples for NF-kappaB analysis were obtained; MAIN OUTCOME MEASURES: Intracellular levels of activated NF-kappaB, in unstimulated and stimulated peripheral blood mononuclear cells at 15 and 30 minutes; OBJECTIVE: To determine the independent and combined effects of pain and opioids on the activation of an early marker of inflammation, nuclear factor-kappaB (NF-kappaB); PARTICIPANTS: Twenty-one (11 female) healthy controls; RESULTS: Neither pain nor opioid administration alone effected NF-kappaB levels in cell populations; however, the combination of treatments induced significant increases of NF-kappaB in stimulated peripheral blood mononuclear cell, lymphocytes, and monocytes; SETTING: University General Clinical Research Center
UR  - http://dx.doi.org/10.5055/jom.2015.0261
ER  -