Intravascular ultrasound analysis to determine the relationship between high-density lipoprotein cholesterol and lesion characteristics in patients with coronary artery disease. 

 -  2014 
<br/><br/> BACKGROUND: Low HDL-C is associated with an increased risk of cardiovascular events. Previous IVUS studies have suggested a significant association between lesion characteristics and cardiovascular events.  CONCLUSIONS: Patients with low levels of HDL-C may be at increased risk of having a higher incidence of attenuated plaques.Copyright © 2014, Wiley Periodicals, Inc.  METHODS: According to HDL-C levels, 120 patients who underwent IVUS for native, de novo coronary lesions before any intervention were divided into a low HDL-C group (<40mg/dL, n=60) and a high HDL-C group (>40mg/dL, n=60). Quantitative and qualitative IVUS analyses were performed to compare lesion characteristics.  OBJECTIVES: This study utilized grayscale intravascular ultrasound (IVUS) to explore the relationship between high-density lipoprotein cholesterol (HDL-C) levels and culprit lesion characteristics in patients with coronary artery disease.  RESULTS: Quantitative IVUS measurements showed no significant differences between the 2 groups. HDL-C level was not significantly correlated with remodeling index (r=0.03, P=0.78). However, attenuated plaque was more frequent in the low HDL-C group (48.3% vs. 28.3%, P=0.02) and a greater percentage of attenuated plaque was found in this group (32.5+/-21.3% vs. 21.0+/-11.0%, P=0.02). Moreover, when categorized into 4 groups according to HDL-C levels, the proportion of attenuated plaque (64.7% in group with <30mg/dL, 41.9% in group with 30-39mg/dL, 36.4% in group with 40-59mg/dL, and 6.3% in group with >60mg/dL; P=0.001 for trend) was significantly different among groups. On multivariate analysis, only HDL-C and male gender were independently associated with the presence of attenuated plaque at the culprit lesions. 
<br/><br/><br/>English 
<br/><br/><label>ISSN: </label>0896-4327 
<br/><br/><label>Subjects--Topical Terms: </label><br/>*Cholesterol, HDL/me [Metabolism]<br/>*Coronary Artery Disease<br/>*Percutaneous Coronary Intervention/mt [Methods]<br/>*Plaque, Atherosclerotic<br/>Aged<br/>Coronary Angiography/mt [Methods]<br/>Coronary Artery Disease/di [Diagnosis]<br/>Coronary Artery Disease/me [Metabolism]<br/>Coronary Artery Disease/th [Therapy]<br/>Female<br/>Humans<br/>Male<br/>Middle Aged<br/>Plaque, Atherosclerotic/pa [Pathology]<br/>Plaque, Atherosclerotic/us [Ultrasonography]<br/>Predictive Value of Tests<br/>Preoperative Care/mt [Methods]<br/>Risk Assessment<br/>Statistics as Topic<br/>Ultrasonography, Interventional/mt [Methods]
<br/><br/><label>Subjects--Geographic Terms: </label><br/>MedStar Health Research Institute<br/>MedStar Heart & Vascular Institute
<br/><br/><label>Index Terms--Function: </label><br/>Journal Article<br/>Randomized Controlled Trial