TY  - BOOK
AU  - Brewer, H Bryan
AU  - Chen, Fang
AU  - Kitabata, Hironori
AU  - Loh, Joshua P
AU  - Magalhaes, Marco A
AU  - Omar, Al Fazir
AU  - Pendyala, Lakshmana K
AU  - Pichard, Augusto D
AU  - Torguson, Rebecca
AU  - Waksman, Ron
TI  - Intravascular ultrasound analysis to determine the relationship between high-density lipoprotein cholesterol and lesion characteristics in patients with coronary artery disease
SN  - 0896-4327
PY  - 2014///
KW  - *Cholesterol, HDL/me [Metabolism]
KW  - *Coronary Artery Disease
KW  - *Percutaneous Coronary Intervention/mt [Methods]
KW  - *Plaque, Atherosclerotic
KW  - Aged
KW  - Coronary Angiography/mt [Methods]
KW  - Coronary Artery Disease/di [Diagnosis]
KW  - Coronary Artery Disease/me [Metabolism]
KW  - Coronary Artery Disease/th [Therapy]
KW  - Female
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - Plaque, Atherosclerotic/pa [Pathology]
KW  - Plaque, Atherosclerotic/us [Ultrasonography]
KW  - Predictive Value of Tests
KW  - Preoperative Care/mt [Methods]
KW  - Risk Assessment
KW  - Statistics as Topic
KW  - Ultrasonography, Interventional/mt [Methods]
KW  - MedStar Health Research Institute
KW  - MedStar Heart & Vascular Institute
KW  - Journal Article
KW  - Randomized Controlled Trial
N2  - BACKGROUND: Low HDL-C is associated with an increased risk of cardiovascular events. Previous IVUS studies have suggested a significant association between lesion characteristics and cardiovascular events; CONCLUSIONS: Patients with low levels of HDL-C may be at increased risk of having a higher incidence of attenuated plaques.Copyright © 2014, Wiley Periodicals, Inc; METHODS: According to HDL-C levels, 120 patients who underwent IVUS for native, de novo coronary lesions before any intervention were divided into a low HDL-C group (<40mg/dL, n=60) and a high HDL-C group (>40mg/dL, n=60). Quantitative and qualitative IVUS analyses were performed to compare lesion characteristics; OBJECTIVES: This study utilized grayscale intravascular ultrasound (IVUS) to explore the relationship between high-density lipoprotein cholesterol (HDL-C) levels and culprit lesion characteristics in patients with coronary artery disease; RESULTS: Quantitative IVUS measurements showed no significant differences between the 2 groups. HDL-C level was not significantly correlated with remodeling index (r=0.03, P=0.78). However, attenuated plaque was more frequent in the low HDL-C group (48.3% vs. 28.3%, P=0.02) and a greater percentage of attenuated plaque was found in this group (32.5+/-21.3% vs. 21.0+/-11.0%, P=0.02). Moreover, when categorized into 4 groups according to HDL-C levels, the proportion of attenuated plaque (64.7% in group with <30mg/dL, 41.9% in group with 30-39mg/dL, 36.4% in group with 40-59mg/dL, and 6.3% in group with >60mg/dL; P=0.001 for trend) was significantly different among groups. On multivariate analysis, only HDL-C and male gender were independently associated with the presence of attenuated plaque at the culprit lesions
ER  -