TY  - BOOK
AU  - Aroda, Vanita R
TI  - Steroid Sex Hormones, Sex Hormone-Binding Globulin, and Diabetes Incidence in the Diabetes Prevention Program
SN  - 0021-972X
PY  - 2015///
KW  - *Androgens/bl [Blood]
KW  - *Diabetes Mellitus, Type 2/bl [Blood]
KW  - *Diabetes Mellitus, Type 2/ep [Epidemiology]
KW  - *Estrogens/bl [Blood]
KW  - *Sex Hormone-Binding Globulin/me [Metabolism]
KW  - Adult
KW  - Aged
KW  - Blood Glucose/an [Analysis]
KW  - Body Mass Index
KW  - Diabetes Mellitus, Type 2/pc [Prevention & Control]
KW  - Female
KW  - Humans
KW  - Incidence
KW  - Male
KW  - Middle Aged
KW  - Polymorphism, Single Nucleotide
KW  - Risk Factors
KW  - Sex Hormone-Binding Globulin/ge [Genetics]
KW  - United States
KW  - Waist Circumference
KW  - MedStar Health Research Institute
KW  - Journal Article
KW  - Multicenter Study
KW  - Randomized Controlled Trial
KW  - Research Support, N.I.H., Extramural
KW  - Research Support, Non-U.S. Gov't
KW  - Research Support, U.S. Gov't, P.H.S
N1  - Available online through MWHC library: 1999- June 2013, Available in print through MWHC library: 1999 - 2006
N2  - CONCLUSIONS: Estrogens and T predicted diabetes risk in men but not in women. SHBG and its polymorphisms did not predict risk in men or women. Diabetes risk is more potently determined by obesity and glycemia than by sex hormones; CONTEXT: Steroid sex hormones and SHBG may modify metabolism and diabetes risk, with implications for sex-specific diabetes risk and effects of prevention interventions; DESIGN AND SETTING: This was a secondary analysis of a multicenter randomized clinical trial involving 27 U.S. academic institutions; INTERVENTIONS: Participants were randomized to receive intensive lifestyle intervention, metformin, or placebo; MAIN OUTCOMES: Associations of steroid sex hormones, SHBG, and SHBG SNPs with glycemia and diabetes risk factors, and with incident diabetes over median 3.0 years (maximum, 5.0 y); OBJECTIVE: This study aimed to evaluate the relationships of steroid sex hormones, SHBG and SHBG single-nucleotide polymorphisms (SNPs) with diabetes risk factors and with progression to diabetes in the Diabetes Prevention Program (DPP); PARTICIPANTS: The study included 2898 DPP participants: 969 men, 948 premenopausal women not taking exogenous sex hormones, 550 postmenopausal women not taking exogenous sex hormones, and 431 postmenopausal women taking exogenous sex hormones; RESULTS: T and DHT were inversely associated with fasting glucose in men, and estrone sulfate was directly associated with 2-hour post-challenge glucose in men and premenopausal women. SHBG was associated with fasting glucose in premenopausal women not taking exogenous sex hormones, and in postmenopausal women taking exogenous sex hormones, but not in the other groups. Diabetes incidence was directly associated with estrone and estradiol and inversely with T in men; the association with T was lost after adjustment for waist circumference. Sex steroids were not associated with diabetes outcomes in women. SHBG and SHBG SNPs did not predict incident diabetes in the DPP population
UR  - http://dx.doi.org/10.1210/jc.2015-2328
ER  -