TY  - BOOK
AU  - Howard, Barbara V
TI  - Insecticide exposure and farm history in relation to risk of lymphomas and leukemias in the Women's Health Initiative observational study cohort
SN  - 1047-2797
PY  - 2015///
KW  - *Agriculture
KW  - *Insecticides/po [Poisoning]
KW  - *Leukemia/ci [Chemically Induced]
KW  - *Leukemia/ep [Epidemiology]
KW  - *Lymphoma/ci [Chemically Induced]
KW  - *Lymphoma/ep [Epidemiology]
KW  - Adult
KW  - Aged
KW  - Cohort Studies
KW  - Female
KW  - Humans
KW  - Middle Aged
KW  - Population Surveillance
KW  - Postmenopause/de [Drug Effects]
KW  - Proportional Hazards Models
KW  - Prospective Studies
KW  - Risk Factors
KW  - Surveys and Questionnaires
KW  - United States/ep [Epidemiology]
KW  - Women's Health
KW  - MedStar Health Research Institute
KW  - Journal Article
KW  - Observational Study
KW  - Research Support, N.I.H., Extramural
KW  - Research Support, N.I.H., Intramural
N2  - CONCLUSIONS: Insecticide exposures may contribute to risk of CLL/SLL and DLBCL. Future studies should examine relationships of LH subtypes with specific types of household insecticides.Copyright © 2015 Elsevier Inc. All rights reserved; METHODS: In questionnaires, women self-reported history living or working on a farm, personally mixing or applying insecticides, insecticide application in the home or workplace by a commercial service, and treating pets with insecticides. Relationships with non-Hodgkin lymphoma (NHL), chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, plasma cell neoplasms, and myeloid leukemia were investigated using Cox proportional hazard models. Age and farming history were explored as effect modifiers; PURPOSE: Relationships of farm history and insecticide exposure at home or work with lymphohematopoietic (LH) neoplasm risk were investigated in a large prospective cohort of US women; RESULTS: The analysis included 76,493 women and 822 NHL cases. Women who ever lived or worked on a farm had 1.12 times the risk of NHL (95% confidence interval [CI] = 0.95-1.32) compared to those who did not. Women who reported that a commercial service ever applied insecticides in their immediate surroundings had 65% higher risk of CLL/SLL (95% CI = 1.15-2.38). Women aged less than 65 years who ever applied insecticides had 87% higher risk of DLBCL (95% CI = 1.13-3.09)
UR  - http://dx.doi.org/10.1016/j.annepidem.2015.08.002
ER  -