TY  - BOOK
AU  - Andalib, Iman
AU  - Finelli, Frederick C
AU  - Koch, Timothy R
AU  - Shope, Timothy R
TI  - Breath Hydrogen as a Biomarker for Glucose Malabsorption after Roux-en-Y Gastric Bypass Surgery
SN  - 0278-0240
PY  - 2015///
KW  - *Breath Tests/mt [Methods]
KW  - *Carbohydrate Metabolism, Inborn Errors/di [Diagnosis]
KW  - *Gastric Bypass/ae [Adverse Effects]
KW  - *Hydrogen/an [Analysis]
KW  - *Malabsorption Syndromes/di [Diagnosis]
KW  - Adult
KW  - Biomarkers/an [Analysis]
KW  - Carbohydrate Metabolism, Inborn Errors/et [Etiology]
KW  - Female
KW  - Humans
KW  - Intestines/mi [Microbiology]
KW  - Malabsorption Syndromes/et [Etiology]
KW  - Male
KW  - Methane/an [Analysis]
KW  - Middle Aged
KW  - MedStar Washington Hospital Center
KW  - Medicine
KW  - Medicine/Gastroenterology
KW  - Surgery
KW  - Evaluation Studies
KW  - Journal Article
N2  - CONCLUSION: These data support the presence of intestinal glucose malabsorption associated with upper gut bacterial overgrowth in individuals with abdominal symptoms after gastric bypass surgery. Breath hydrogen testing after oral glucose should be considered to evaluate potential malabsorption in symptomatic, postoperative individuals; METHODS: This is a retrospective study of individuals (n = 63; 60 females; 3 males; mean age 49 years) who had gastric bypass surgery and then glucose breath testing to evaluate abdominal symptoms; OBJECTIVE: Abdominal symptoms are common after bariatric surgery, and these individuals commonly have upper gut bacterial overgrowth, a known cause of malabsorption. Breath hydrogen determination after oral glucose is a safe and inexpensive test for malabsorption. This study is designed to investigate breath hydrogen levels after oral glucose in symptomatic individuals who had undergone Roux-en-Y gastric bypass surgery; RESULTS: Among 63 postoperative individuals, 51 (81%) had a late rise (>45 minutes) in breath hydrogen or methane, supporting glucose malabsorption; 46 (90%) of these 51 subjects also had an early rise (<30 minutes) in breath hydrogen or methane supporting upper gut bacterial overgrowth. Glucose malabsorption was more frequent in subjects with upper gut bacterial overgrowth compared to subjects with no evidence for bacterial overgrowth (P < 0.001)
UR  - http://dx.doi.org/10.1155/2015/102760
ER  -