Small-particle Inhaled Corticosteroid as First-line or Step-up Controller Therapy in Childhood Asthma. 

 -  2015 
<br/><br/> BACKGROUND: Because randomized controlled trials of established pediatric asthma therapies are expensive and difficult to perform, observational studies may fill gaps in the evidence base.  CONCLUSIONS: Initiating or stepping up the ICS dose with small-particle ICS rather than with standard size-particle ICS is more effective and shows similar effectiveness to add-on LABA in childhood asthma.Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.  METHODS: These historical matched cohort analyses drew on electronic medical records of children with asthma aged 5 to 11 years. Variables measured during 2 consecutive years (1 baseline year for confounder definition and 1 outcome year) included risk-domain asthma control (no hospital attendance for asthma, acute oral corticosteroids, or lower respiratory tract infection requiring antibiotics) and rate of severe exacerbations (asthma-related emergency, hospitalization, or oral corticosteroids).  OBJECTIVES: To compare the effectiveness of representative small-particle inhaled corticosteroid (ICS) with that of standard size-particle ICS for children initiating or stepping up ICS therapy for asthma (analysis 1) and to compare the effectiveness of ICS dose step-up using small-particle ICS with adding long-acting beta2-agonist (LABA) to the ICS (analysis 2).  RESULTS: In the initiation population (n = 797 in each cohort), children prescribed small-particle ICS versus standard size-particle ICS experienced greater odds of asthma control (adjusted odds ratio, 1.49; 95% CI, 1.10-2.02) and lower severe exacerbation rate (adjusted rate ratio, 0.56; 95% CI, 0.35-0.88). Step-up outcomes (n = 206 in each cohort) were also significantly better for small-particle ICS, with asthma control adjusted odds ratio of 2.22 (95% CI, 1.23-4.03) and exacerbations adjusted rate ratio of 0.49 (95% CI, 0.27-0.89). The number needed to treat with small-particle ICS to achieve 1 additional child with asthma control was 17 (95% CI, 9-107) for the initiation population and 5 (95% CI, 3-78) for the step-up population. Outcomes were not significantly different for stepped-up small-particle ICS dose versus ICS/LABA combination (n = 185 in each cohort). 
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<br/><br/><label>Subjects--Topical Terms: </label><br/>*Adrenal Cortex Hormones/ad [Administration & Dosage]<br/>*Adrenergic beta-2 Receptor Agonists/ad [Administration & Dosage]<br/>*Asthma/dt [Drug Therapy]<br/>*Microspheres<br/>*Particle Size<br/>Administration, Inhalation<br/>Adrenal Cortex Hormones/ae [Adverse Effects]<br/>Adrenergic beta-2 Receptor Agonists/ae [Adverse Effects]<br/>Child<br/>Child, Preschool<br/>Cohort Studies<br/>Drug Dosage Calculations<br/>Female<br/>Follow-Up Studies<br/>Humans<br/>Male<br/>Treatment Outcome
<br/><br/><label>Subjects--Geographic Terms: </label><br/>MedStar Washington Hospital Center
<br/><br/><label>Index Terms--Occupation: </label><br/>Medicine/Pulmonary-Critical Care
<br/><br/><label>Index Terms--Function: </label><br/>Comparative Study<br/>Journal Article<br/>Observational Study<br/>Research Support, Non-U.S. Gov't