TY  - BOOK
AU  - Hwang, Jonathan J
AU  - Verghese, Mohan
TI  - Differences in the aggressiveness of prostate cancer among Korean, Caucasian, and African American men: A retrospective cohort study of radical prostatectomy
SN  - 1078-1439
KW  - *African Americans/sn [Statistics & Numerical Data]
KW  - *Asian Americans/sn [Statistics & Numerical Data]
KW  - *European Continental Ancestry Group/sn [Statistics & Numerical Data]
KW  - *Prostatectomy
KW  - *Prostatic Neoplasms/pa [Pathology]
KW  - Adult
KW  - Aged
KW  - Aged, 80 and over
KW  - Follow-Up Studies
KW  - Humans
KW  - Incidence
KW  - Male
KW  - Middle Aged
KW  - Neoplasm Grading
KW  - Neoplasm Staging
KW  - Prognosis
KW  - Prostate-Specific Antigen/bl [Blood]
KW  - Prostatic Neoplasms/bl [Blood]
KW  - Prostatic Neoplasms/ep [Epidemiology]
KW  - Prostatic Neoplasms/su [Surgery]
KW  - Retrospective Studies
KW  - United States/ep [Epidemiology]
KW  - MedStar Washington Hospital Center
KW  - Urology
KW  - Journal Article
N2  - CONCLUSIONS: There are differences in PCa aggressiveness between Korean and Western men. The incidence of high-grade or advanced-stage PCa is higher in Korean men.Copyright (c) 2016 Elsevier Inc. All rights reserved; METHODS: We performed a retrospective cohort study of 1,939 patients who underwent radical prostatectomy for clinically localized PCa in the Asan Medical Center and Washington Hospital Center. After adjusting for confounding clinical variables, we used multivariate logistic regression analysis to assess differences in the aggressiveness of PCa; PURPOSE: We aimed to compare the pathologic aggressiveness of clinically localized prostate cancer (PCa) treated by radical prostatectomy in Korean and Western (Caucasian and African American [AA]) men by analyzing data from representative hospitals in the capitals of Korea (Seoul) and the United States (Washington, DC); RESULTS: We analyzed 1,152 Korean, 473 Caucasian, and 314 AA patients. There were significant differences between Korean and Western patients in terms of age at surgery, preoperative levels of prostate-specific antigen, and clinical stage (P<0.001). Overall, high-grade PCa (Gleason score>8) was more common in Korean (19.4%) than in AA (6.1%) or Caucasian (5.5%) patients (P<0.001). The incidence of advanced-stage PCa (pT3 or higher) was higher in Korean (34.8%) than in AA (18.2%) or Caucasian (13.3%) patients (P<0.001). After adjusting for age, prostate-specific antigen, prostate volume, and clinical stage, multivariate logistic regression analysis showed that Korean men had a high risk of high-grade PCa (Korean vs. Caucasian, odds ratio [OR] = 3.48, P<0.001; Korean vs. AA, OR=3.14, P<0.001) or advanced-stage PCa (Korean vs. Caucasian, OR=2.40, P<0.001; Korean vs. AA, OR = 1.59, P = 0.009) than Western men
UR  - http://dx.doi.org/10.1016/j.urolonc.2015.08.004
ER  -