TY  - BOOK
AU  - Garcia-Garcia, Hector M
TI  - Serial volumetric assessment of coronary fibroatheroma by optical frequency domain imaging: insights from the TROFI trial
SN  - 2047-2404
PY  - 2017///
KW  - *Coronary Artery Disease/dg [Diagnostic Imaging]
KW  - *Plaque, Atherosclerotic/dg [Diagnostic Imaging]
KW  - *ST Elevation Myocardial Infarction/th [Therapy]
KW  - *Thrombectomy/mt [Methods]
KW  - *Tomography, Optical Coherence/mt [Methods]
KW  - Aged
KW  - Combined Modality Therapy
KW  - Coronary Artery Disease/th [Therapy]
KW  - Female
KW  - Follow-Up Studies
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - Percutaneous Coronary Intervention
KW  - Plaque, Atherosclerotic/su [Surgery]
KW  - Prospective Studies
KW  - Risk Assessment
KW  - ST Elevation Myocardial Infarction/dg [Diagnostic Imaging]
KW  - ST Elevation Myocardial Infarction/mo [Mortality]
KW  - Survival Rate
KW  - Time Factors
KW  - Treatment Outcome
KW  - MedStar Heart & Vascular Institute
KW  - Journal Article
N2  - Aims: Coronary lesions precursors of acute events remain elusive, since they undergo continuous changes and their temporal changes are not very well-characterized. In natural history studies, optical frequency domain imaging (OFDI) has been used only to assess fibroatheromas as a 2D structure and sometimes in a single frame fashion. We aim at describing the serial volumetric modifications of the fibrous cap (FC) of the fibroatheromas as determined by OFDI over a 6-month follow-up period; Conclusions: Non-culprit fibroatheromas located in the infarct related artery of patients with STEMI had a volumetric reduction of the FC after 6-month follow-up. Quantitative FC assessment was able to differentiate high-risk lesions that became ThCFAs. There was a considerable change of plaque phenotype (TCFAs or ThCFAs) over time; Copyright Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2017. For permissions, please email: journals.permissions@oup.com; Methods and results: In 49 patients, OFDI investigation was performed following treatment of culprit lesion and at 6-month follow-up in patients with ST-segment elevation myocardial infarction (STEMI). A fully automatic volumetric quantification of FC was done in all lipid-containing frames of non-culprit lesions in the infarct related artery. These lesions were matched at baseline and 6-month follow-up. A total of 58 non-culprit lipid rich lesions (34 TCFAs and 24 thick-cap fibroatheroma [ThCFA]) were found in 34 patients at baseline. Overall, there was a FC volume decrease of 1.57 (Inter-quartile Range [IQR] -4.13 to 0.54) mm3 at 6-months. 27% of the lesions changed their phenotype over time (TCFA or ThCFA). TCFAs that became ThCFAs at follow-up had smaller mean and maximal FC as compared with lesions that remained TCFAs (P = 0.01 for both)
UR  - https://dx.doi.org/10.1093/ehjci/jew338
ER  -