Cardio-oncology Related to Heart Failure: Epidermal Growth Factor Receptor Target-Based Therapy. [Review] 

 -  2017 
<br/><br/> Cancer therapy targeting the epidermal growth factor receptor (EGFR)/erythroblastic leukemia viral oncogene B (ErbB)/human EGFR receptor (HER) family of tyrosine kinases has been successfully used in treatment of several malignancies. The ErbB pathways play a role in the maintenance of cardiac homeostasis. This article summarizes current knowledge about EGFR/ErbB/HER receptor-targeted cancer therapeutics focusing on their cardiotoxicity profiles, molecular mechanisms, and implications in clinical cardio-oncology. The article discusses challenges in predicting, monitoring, and treating cardiac dysfunction and heart failure associated with ErbB-targeted cancer therapeutics and highlights opportunities for researchers and clinical investigators.  Copyright (c) 2016 Elsevier Inc. All rights reserved. 
<br/><br/><br/>English 
<br/><br/><label>ISSN: </label>1551-7136 
<br/><br/><label>Subjects--Topical Terms: </label><br/>*Heart Failure/ci [Chemically Induced]<br/>*Neoplasms/dt [Drug Therapy]<br/>*Protein Kinase Inhibitors/ae [Adverse Effects]<br/>Heart Failure/me [Metabolism]<br/>Heart Failure/pp [Physiopathology]<br/>Heart Ventricles/pp [Physiopathology]<br/>Humans<br/>Neoplasms/me [Metabolism]<br/>Neoplasms/pp [Physiopathology]<br/>Protein Kinase Inhibitors/pd [Pharmacology]<br/>Receptor, Epidermal Growth Factor/ai [Antagonists & Inhibitors]<br/>Signal Transduction/de [Drug Effects]<br/>Ventricular Function, Left/de [Drug Effects]
<br/><br/><label>Subjects--Geographic Terms: </label><br/>MedStar Heart & Vascular Institute<br/>MedStar Washington Hospital Center
<br/><br/><label>Index Terms--Occupation: </label><br/>Medicine/Cardiology
<br/><br/><label>Index Terms--Function: </label><br/>Journal Article<br/>Review