TY  - BOOK
AU  - Goyal, Munish
TI  - The association between hemoglobin concentration and neurologic outcome after cardiac arrest
SN  - 0883-9441
PY  - 2016///
KW  - *Anemia/ep [Epidemiology]
KW  - *Cardiopulmonary Resuscitation/mt [Methods]
KW  - *Heart Arrest/th [Therapy]
KW  - *Hemoglobins/me [Metabolism]
KW  - *Hypothermia, Induced/mt [Methods]
KW  - *Hypoxia, Brain/pp [Physiopathology]
KW  - *Registries
KW  - Adult
KW  - Aged
KW  - Aged, 80 and over
KW  - Anemia/me [Metabolism]
KW  - Cohort Studies
KW  - Comorbidity
KW  - Female
KW  - Heart Arrest/co [Complications]
KW  - Heart Arrest/ep [Epidemiology]
KW  - Heart Arrest/me [Metabolism]
KW  - Humans
KW  - Hypoxia, Brain/et [Etiology]
KW  - Male
KW  - Middle Aged
KW  - Neoplasms/ep [Epidemiology]
KW  - Odds Ratio
KW  - Renal Insufficiency/ep [Epidemiology]
KW  - Retrospective Studies
KW  - Survival Rate
KW  - Treatment Outcome
KW  - MedStar Washington Hospital Center
KW  - Emergency Medicine
KW  - Journal Article
N1  - Available online through MWHC library: 2012 - present
N2  - CONCLUSION: Higher Hgb after cardiac arrest is associated with favorable neurologic outcome, particularly within the first 6 hours. It is unclear if this effect is due to impaired oxygen delivery or if Hgb is a marker for more severe illness; Copyright (c) 2016 Elsevier Inc. All rights reserved; METHODS: We conducted a retrospective cohort study using the Penn Alliance for Therapeutic Hypothermia (PATH) cardiac arrest registry. Inclusion criteria were resuscitated cardiac arrest (inhospital or out of hospital) and an Hgb value recorded within 24 hours of return of spontaneous circulation. The primary outcome was favorable neurologic status at hospital discharge. Survival to hospital discharge was a secondary outcome; PURPOSE: The purpose of the study is to determine the association between hemoglobin concentration (Hgb) and neurologic outcome in postarrest patients; RESULTS: There were 598 eligible patients from 21 hospitals. Patients with favorable neurologic outcome had significantly higher median Hgb in the first 2 hours (12.7 vs 10.5 g/dL; P<.001) and 6 hours (12.6 vs 10.6 g/dL; P<.001) postarrest. Controlling for age, pulseless rhythm, etiology, location of arrest, receipt of targeted temperature management, hematologic or metastatic malignancy, or preexisting renal insufficiency, there was a significant relationship between Hgb and neurologic outcome within the first 6 hours after arrest (odds ratio, 1.23; 95% confidence interval, 1.09-1.38) and survival to hospital discharge (odds ratio, 1.20; 95% confidence interval, 1.08-1.34)
UR  - https://dx.doi.org/10.1016/j.jcrc.2016.07.012
ER  -