TY  - BOOK
AU  - Howard, Barbara V
TI  - The effect of genetic variants on the relationship between statins and breast cancer in postmenopausal women in the Women's Health Initiative observational study
SN  - 0167-6806
PY  - 2018///
KW  - *Breast Neoplasms/dt [Drug Therapy]
KW  - *Cholesterol/ge [Genetics]
KW  - *Genetic Predisposition to Disease
KW  - *Hydroxymethylglutaryl-CoA Reductase Inhibitors/ad [Administration & Dosage]
KW  - Aged
KW  - Anticholesteremic Agents/ad [Administration & Dosage]
KW  - Anticholesteremic Agents/ae [Adverse Effects]
KW  - Breast Neoplasms/ge [Genetics]
KW  - Breast Neoplasms/pa [Pathology]
KW  - Cholesterol/me [Metabolism]
KW  - Female
KW  - Genome-Wide Association Study
KW  - Humans
KW  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/ae [Adverse Effects]
KW  - Middle Aged
KW  - Polymorphism, Single Nucleotide/ge [Genetics]
KW  - Postmenopause
KW  - Risk Assessment
KW  - Risk Factors
KW  - Women's Health
KW  - MedStar Health Research Institute
KW  - Journal Article
N1  - Available online from MWHC library: 1997 - present
N2  - CONCLUSIONS: We found no evidence of SNP interactions with statin usage for breast cancer risk in a population of 3374 individuals. These results suggest that genome-wide common genetic variants do not moderate the association between statin usage and breast cancer in the population of women in the Women's Health Initiative; METHODS: To identify candidate gene-statin interactions, we tested interactions between 22 SNPS in nine candidate genes implicated in the effect of statins on lipid metabolism in 1687 cases and 1687 controls. We then evaluated statin use interaction with the remaining 30,380 SNPs available in this sample from the CGEMS GWAS study; PURPOSE: Statins have been postulated to have chemopreventive activity against breast cancer. We evaluated whether germline genetic polymorphisms modified the relationship between statins and breast cancer risk using data from the Women's Health Initiative. We evaluated these interactions using both candidate gene and agnostic genome-wide approaches; RESULTS: After adjusting for multiple comparisons, no SNP interactions with statin usage and risk of breast cancer were statistically significant in either the candidate genes or genome-wide approaches
UR  - https://dx.doi.org/10.1007/s10549-017-4521-0
ER  -