TY  - BOOK
AU  - Mazer-Amirshahi, Maryann
TI  - Emergency department approach to QTc prolongation. [Review]
SN  - 0735-6757
PY  - 2017///
KW  - *Anti-Bacterial Agents/ae [Adverse Effects]
KW  - *Antiemetics/ae [Adverse Effects]
KW  - *Antipsychotic Agents/ae [Adverse Effects]
KW  - *Emergency Service, Hospital
KW  - *Long QT Syndrome/di [Diagnosis]
KW  - *Torsades de Pointes/di [Diagnosis]
KW  - Drug Overdose/co [Complications]
KW  - Drug Overdose/pp [Physiopathology]
KW  - Electrocardiography
KW  - Guideline Adherence
KW  - Humans
KW  - Long QT Syndrome/ci [Chemically Induced]
KW  - Practice Patterns, Physicians'
KW  - Risk Factors
KW  - Torsades de Pointes/ci [Chemically Induced]
KW  - United States/ep [Epidemiology]
KW  - MedStar Washington Hospital Center
KW  - Emergency Medicine
KW  - Journal Article
KW  - Review
N1  - Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006
N2  - QTc prolongation has been associated with increased risk of developing ventricular tachydysrhythmias, particularly Torsades de Pointes (TdP). QTc prolongation is influenced by many factors including congenital causes, heart rate, metabolic imbalances, and pharmacotherapy. Several commonly used medications in the emergency department (ED), such as antipsychotics and antiemetics, are known to prolong the QT interval. In addition, ED patients may present with conditions that may predispose them to QTc prolongation, such as drug overdose or hypokalemia, which can further complicate management. ED providers should not only be aware of which medications have these effects, but must also thoroughly investigate any pertinent patient history that may contribute to QTc prolongation. This review discusses commonly encountered medications that are associated with QTc prolongation, the mechanisms by which they prolong the QTc interval, and other factors that may influence ED medication administration and management. Copyright (c) 2017 Elsevier Inc. All rights reserved
UR  - https://dx.doi.org/10.1016/j.ajem.2017.08.044
ER  -