TY  - BOOK
AU  - Sandfort, Veit
AU  - Vargas, Jose D
TI  - Prolonged Elevated Heart Rate and 90-Day Survival in Acutely Ill Patients: Data From the MIMIC-III Database
SN  - 0885-0666
PY  - 2019///
KW  - *Critical Illness/mo [Mortality]
KW  - *Tachycardia/mo [Mortality]
KW  - Acute Disease
KW  - Adult
KW  - Aged
KW  - Critical Care
KW  - Databases, Factual
KW  - Female
KW  - Follow-Up Studies
KW  - Humans
KW  - Intensive Care Units
KW  - Logistic Models
KW  - Male
KW  - Middle Aged
KW  - Monitoring, Physiologic
KW  - Multivariate Analysis
KW  - Prognosis
KW  - Tachycardia/di [Diagnosis]
KW  - Time Factors
KW  - MedStar Health Research Institute
KW  - MedStar Washington Hospital Center
KW  - Medicine/Internal Medicine
KW  - Journal Article
N1  - Available in print through MWHC library: 1992 - 2001
N2  - CONCLUSION: We found a significant association of peHR with decreased survival in a large and heterogenous cohort of ICU patients; METHODS: We used a large observational intensive care unit (ICU) database (Multiparameter Intelligent Monitoring in Intensive Care III [MIMIC-III]), where frequent heart rate measurements were available. The peHR was defined as a heart rate >100 beats/min in 11 of 12 consecutive hours. The outcome was survival status at 90 days. We collected heart rates, disease severity (simplified acute physiology scores [SAPS II]), comorbidities (Charlson scores), and International Classification of Diseases (ICD) diagnosis information in 31 513 patients from the MIMIC-III ICU database. Propensity score (PS) methods followed by inverse probability weighting based on the PS was used to balance the 2 groups (the presence/absence of peHR). Multivariable weighted logistic regression was used to assess for association of peHR with the outcome survival at 90 days adjusting for additional covariates; PURPOSE: We sought to evaluate the association of prolonged elevated heart rate (peHR) with survival in acutely ill patients; RESULTS: The mean age was 64 years, and the most frequent main disease category was circulatory disease (41%). The mean SAPS II score was 35, and the mean Charlson comorbidity score was 2.3. Overall survival of the cohort at 90 days was 82%. Adjusted logistic regression showed a significantly increased risk of death within 90 days in patients with an episode of peHR ( P < .001; odds ratio for death 1.79; confidence interval, 1.69-1.88). This finding was independent of median heart rate
UR  - https://dx.doi.org/10.1177/0885066618756828
ER  -